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Flashcards 241 Flashcards
Students 10 Students
Language English
Level University
Created / Updated 23.06.2020 / 31.12.2020
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0 Exact answers 0 Text answers 241 Multiple-choice answers

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Which of the following statements characterizes ELISA

Method for quantitative determination of XXX

Synonym for immunodiffusion

Immunoenzymatic method for the determination // antibody

Immunofluorescence test for detection of antigen and antibody

Quantitative nephelometric method

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Which of the following statements describe Chemotaxis

No directed movement of cells induced by chemical substance

An orientated cell movement in chemotactic factor gradient

An orientated cell movement induced by hematoxylin

An orientated cell movement induced by eosin

No directed movement of cells induced by latex gradient

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Which of the following statements describe principle of the mixed lymphocyte reaction (MLR) method

 

T-cells derived from genetically different donors cultured together and result/ proliferation

T cells from the same donor genetically cultured together result strong p/

T cells from genetically different donors cultured together do not undergo // proliferation

T cells from the same donors genetically cultured together result the weak // proliferation

T cells derived from genetically different donors cultured together underg/

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Which of the following statements does NOT apply to M cells present in GALT

Capture macromolecules and microorganisms from the intestinal lumen

Have a limited capacity of degradation of absorbed particles

Present antigens to CD4+ T cells

Take part in the selective transport of absorbed particles into the deeper layer of mucosa

They are part of Peyer’s patches

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Which of the proposed methods will be most effective in preventing "graft versus host" disease in bone marrow transplant recipients:

IFN-alpha administration

Assessment of component donor and recipient complement

Removal of mature T lymphocytes from the transplant

Removal of pre-B lymphocytes from the transplant

Assessment of HLA antigens in donor and recipient

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Which of the statements describing the essential activities of cells participating in an immune response is unreasonable:

Dendritic cells - present antigens to auxiliary lymphocytes (= T Helpers)

NK cells - capable of specifically identifying cells infected with the virus

Eosinophile - capable of controlling parasites

B-lymphocytes recognize protein antigens presenting auxiliary lymphocytes

Tc lymphocytes capable of cytotoxicity and production of perfumers and granzymes

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Which of the statements regarding tolerance is (False):

Tolerance is more easily induced in T cells than in B cells

Tolerance is easier to induce in neonates than in adults

Tolerance is easier to induce on one particular molecule than on complex particles

Tolerance is not antigenic specific

Molecular mimics are not a mechanism of tolerance

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Which of the T cells regulate eosinophil and basophil function

Th3

Th9

Th1

Th2

Th17

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Which type of hypersensitivity best describes neonatal hemolytic disease caused by incompatibility in the Rh range:

anaphylactic

Cytotoxic

Immune complexes

Delayed

atopic

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Mark incorrect answer

Immunologic tolerance mean no action of immune system against autoantigens

Cells recognizing autoantigens are produced continuously during development

Problems with immune tolerance leads to autoimmunity disease development

Low number of autoantigens has a direct contact with immune system

There are 2 basic types of immune tolerance: central and peripheral

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Type I interferons (IFNa, IGNß) are important in nonspecific antiviral immune response. Mark wrong answer

They are produced by cells infected by a virus

They bin to receptors located on infected cells

They increase cytotoxic activity of NK cells

Non infected cells may recognize them by receptors-this may lead to protection agains infection (so-called antiviral state)

They inhibit MHC I synthesis on infected cells

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Mark answer that contains only adaptive immune response elements

Th, antibodies

Natureal antibodies, NK cells, CTLs

Phagocytes, Tregs, natural barriers

Natural antibodies, macrophages

Complement, natural barriers, NKT cells

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APCs that activate T helper cells need to have the following molecule on their surface:

IFNy

MHC I

TCR

BCR

MHC II

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Which of the cytokines below induce pyrogenic effects

IL-2

IL-3

IL-4

IL-1

IL-5

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The correct statement describing the human major histocompatibility complex (MHC) should be:

MHC class I include HLA-A, HLA-B, HLA-C

MHC class II molecules, present peptides to T CD8+ cells

MHC class I molecules, present mainly in APCs present peptides to T CD4+ cells

MHC class II presentation system covers mostly self-antigens, viral antigens and tumor antigens

MHC class I presentation system covers mostly antigens derived from extracellular pathogens

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During immune complex binding complement protein C1q attaches to

constant region Fc of an Ab

fab region of an Ab

hypervariable region of an Ab

light chain region of an Ab

framework region of an Ab

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The regulatory T lymphocytes function can e characterized with the following statement

Tregs may inhibit autoreactive lymphocytes

Tregs may inhibit hypersensitivity reactions

Tregs may be responsible for developing tolerance to tumor antigens

Tregs play a role in the food tolerance development

All are correct

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Mark incorrect answer

specificity means the ability of immune system ro react on various antigens in a different way

passive adoptive immunity do not lead to memory development

T-naive cells are cells that have never men antigent on the periphery they are specific for

clonal expansion of lymphocytes means its intensive apoptosis

plasmatic cells are crucial for humoral immunity

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Clonal deletion of lymphocytes during peripheral tolerance development means

Apoptosis of alloreactive naive T-cells

Apoptosis of mature autoreactive lymphocytes

Apoptosis of myeloid cell progenitors

V and J gene rearrangement in TCR

Cell activation by co-stimulatory signal

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IgA Antibody directed against outer membrane protein (OmpA-1) may be recognized

 

Specifically by FcR

Nonspecifically by FcR

Nonspecifically by OmpA-1 protein

Specifically by PAMP

By none of the above mentioned

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Naive lymphocytes needs direct interaction with antigen presenting cell to be activated. So-called first signal of activation comes from

Recognition of an antigen via MHCII molecules

Recognition of an antigen via MHCI molecules

Recognition of an antigen vi TCR or BCR

Activated CTLA-4 molecule on lymphocytes

Activated CD80/CD86 molecules on APC

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CD80/CD86 surface molecules on antigen presenting cells are needed for

Specific antigen recognition

Specific activation of TCR on T-cells

Co-stimulation necessary for T-cell activation

For development of so-called 1st signal for T-cell activation

For development of so-called 2nd signal for APC

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The T-cell that encounters an antigen for which it has a specific receptor may finally

Be activated into an effector cell

Be activated into a memory cell

Be activated and/or undergo apoptosis

Ignore the presence of the antigen

All answers are correct

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CTLA-4 molecule induced on T-cell surface is responsible for 

transduction of cell activating signal

transduction of signal for lymphocytes anergy

transduction of signal for immunosuppressive cytokine production

transduction of cell inhibiting signal

transduction of signal for lymphocytes apoptosis

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The most important role in combating of fungal infections is played by

specific IgG antibodies

natural IgM antibodies

NK cells

neutrophils, macrophages, CTLs

eosinophils and mast cells

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which of the Th cells regulate neutrophils function

Th3

Th9

Th1

Th2

Th17

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which of the Th cells regulate macrophage function

Th3

Th9

Th1

Th2

Th17

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Mark CORRECT answer describing innate immunity

Needs adoptive immunity for development

Leaves immune memory

Needs contact with allergen

Do not induce autoagression

Induce autoagression

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Disease endotype is characterized by:

Different pathomechanism

Specific factor (S) inducing disease symptoms

Specifics et of disease symptoms

Specific phenotype of the patient

None of the above mentioned

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Mannose and lectine receptors are mainly involved in

Phagocyte’s apoptosis activation

Recognition of so called PAMP’s on microorganisms

Phagocyte’s ROS neutralization

Cytotoxicity of CTLs

Development of immune memory