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Fenster schliessen

During immune complex binding complement protein C1q attaches to

constant region Fc of an Ab

fab region of an Ab

hypervariable region of an Ab

light chain region of an Ab

framework region of an Ab

Fenster schliessen

The regulatory T lymphocytes function can e characterized with the following statement

Tregs may inhibit autoreactive lymphocytes

Tregs may inhibit hypersensitivity reactions

Tregs may be responsible for developing tolerance to tumor antigens

Tregs play a role in the food tolerance development

All are correct

Fenster schliessen

Mark incorrect answer

specificity means the ability of immune system ro react on various antigens in a different way

passive adoptive immunity do not lead to memory development

T-naive cells are cells that have never men antigent on the periphery they are specific for

clonal expansion of lymphocytes means its intensive apoptosis

plasmatic cells are crucial for humoral immunity

Fenster schliessen

Clonal deletion of lymphocytes during peripheral tolerance development means

Apoptosis of alloreactive naive T-cells

Apoptosis of mature autoreactive lymphocytes

Apoptosis of myeloid cell progenitors

V and J gene rearrangement in TCR

Cell activation by co-stimulatory signal

Fenster schliessen

IgA Antibody directed against outer membrane protein (OmpA-1) may be recognized

 

Specifically by FcR

Nonspecifically by FcR

Nonspecifically by OmpA-1 protein

Specifically by PAMP

By none of the above mentioned

Fenster schliessen

Naive lymphocytes needs direct interaction with antigen presenting cell to be activated. So-called first signal of activation comes from

Recognition of an antigen via MHCII molecules

Recognition of an antigen via MHCI molecules

Recognition of an antigen vi TCR or BCR

Activated CTLA-4 molecule on lymphocytes

Activated CD80/CD86 molecules on APC

Fenster schliessen

CD80/CD86 surface molecules on antigen presenting cells are needed for

Specific antigen recognition

Specific activation of TCR on T-cells

Co-stimulation necessary for T-cell activation

For development of so-called 1st signal for T-cell activation

For development of so-called 2nd signal for APC

Fenster schliessen

The T-cell that encounters an antigen for which it has a specific receptor may finally

Be activated into an effector cell

Be activated into a memory cell

Be activated and/or undergo apoptosis

Ignore the presence of the antigen

All answers are correct

Fenster schliessen

CTLA-4 molecule induced on T-cell surface is responsible for 

transduction of cell activating signal

transduction of signal for lymphocytes anergy

transduction of signal for immunosuppressive cytokine production

transduction of cell inhibiting signal

transduction of signal for lymphocytes apoptosis

Fenster schliessen

The most important role in combating of fungal infections is played by

specific IgG antibodies

natural IgM antibodies

NK cells

neutrophils, macrophages, CTLs

eosinophils and mast cells

Fenster schliessen

which of the Th cells regulate neutrophils function

Th3

Th9

Th1

Th2

Th17

Fenster schliessen

which of the Th cells regulate macrophage function

Th3

Th9

Th1

Th2

Th17

Fenster schliessen

Mark CORRECT answer describing innate immunity

Needs adoptive immunity for development

Leaves immune memory

Needs contact with allergen

Do not induce autoagression

Induce autoagression

Fenster schliessen

Disease endotype is characterized by:

Different pathomechanism

Specific factor (S) inducing disease symptoms

Specifics et of disease symptoms

Specific phenotype of the patient

None of the above mentioned

Fenster schliessen

Mannose and lectine receptors are mainly involved in

Phagocyte’s apoptosis activation

Recognition of so called PAMP’s on microorganisms

Phagocyte’s ROS neutralization

Cytotoxicity of CTLs

Development of immune memory

Fenster schliessen

Indicate the CORRECT antibody characteristic

Antibodies are characteristic by low immunogenicity

The rheumatoid factor is an anti-IgE antibody

Anti-idiotypic antibodies are directed against Fc protein determinants of another antibody

IgE antibody is the most abundant serum immunoglobulin

Immunotoxins and immunocytokines are the examples of conjugated monoclonal antibodies

Fenster schliessen

Which mechanism(s) protect the organism against autoimmunity

Clonal deletion

Lymphocyte anergy

The antigen ignorance or sequestration

Active suppression by regulatory T-cells

All answers are correct

Fenster schliessen

Select the CORRECT statement concerning NKT lymphocytes

They regulate cell function by secreting IL-10

They possess both innate and acquired immune response characteristic

They do not secrete IFN-y (strong macrophage activator)

The do not recognize glycolipid antigens, which are presented by CD1d

They have both BCR receptor and NK cell characteristic

Fenster schliessen

Defensins, proteins with natural antibiotic properties, may kill some microorganisms. They are produced at large amounts mainly by:

NK cells

B cells

T CD4+ cells

Paneth cells in the intestine

Mast cells

Fenster schliessen

Underline CORRECT statement describing T-gamma-delta cells

They have TCRs on the cell surface

They recognize antigens in the context of MHC molecules

They do not play an important role in skin and mucosal immunity

They do not play an important role in both adoptive and innate immunity

They do not produce cytokines

Fenster schliessen

The immune autotolerance is possible due to existence of various central and peripheral mechanisms which do NOT include:

Sequestration of an antigen

Clonal deletion of lymphocytes

Clonal anergy of lymphocytes

Deletion of autoreactive T-cell clones

Antigenic molecule mimicry

Fenster schliessen

The immunophenotype: TCR CD2+ CD3- CD4- CD8- CD16+ CD19- CD20- CD56+, defines

Regulatory T cell

Cytotoxic T cell

Helper T cell

NK cell

B cell

Fenster schliessen

The main site of the gastrointestinal tract mucous membrane immune response induction is:

mesenteric lymph nodes

single lymphatic nodule

mucosal lamina prorpia

Peyer's patch

intestinal lumen

Fenster schliessen

The hypersensitivity type IVb cell infiltration (by G&C, modified) involves essentially

Th1 lymphocytes and eosinophils

Th2 lymphocytes and eosinophils

Th1lymphocytesandmacrophages

Th 17 cells and neutrophils

Th2 lymphocytes and macrophages

Fenster schliessen

The clinical syndrome, that is NOT accompanied by primary combined immunodeficiency is:

DiGeorge syndrome

Ataxia-telangiectasia

Nijmengensyndrome

Wiskott-Aldrich syndrome

Bruton syndrome

Fenster schliessen

Severe combined immunodeficiency (SCID) is associated basically with: 

Dysfunction of T-cells and macrophages

Selectively impaired B-cell function

Impairment of T-cells, B-cells and NK-cells

dysfunction of T cells and B-cells exclusively

Dysfunction of phagocytes

Fenster schliessen

Autoantibodies against acetylcholine receptors are typically detected in the serum of patients with:

Myasthenia gravis

Multiple sclerosis

Lupuserythematosus

Celiac disease

Crohn’s disease

Fenster schliessen

The formation of coronary artery aneurysms and heart attack symptoms in children, resulting from hypersensitivity vasculitis (type II by Gell and Coombs) appears in:

Takayasu’s disease

Schoenlein-Henoch purpura

Kawasaki disease

Churg-Strauss syndrome

Hashimoto’s disease

Fenster schliessen

Multiple myeloma is defined as a clonal proliferation of:

Plasma cells

Cytotoxic cells

Myeloidcells

T lymphocytes

NKT cells

Fenster schliessen

T CD8+ lymphocytes usually recognize the target presented in the restriction of:

Antibody Fab portion

Complement C5a and C3a molecules

HLA-DQmolecules

HLA-B molecules

MHC class III