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Fenster schliessen

Leptospira has 2 species name them:

Leptospira interrogans - pathogenic species 

Leptospira biflexa - saprophytes

Fenster schliessen

Name non-flexible spiral bacteria 

  • helicobacter 
  • campylobacter 
  • vibrio 
Fenster schliessen

Name flexible spiral bacteria 

  • Treponema 
  • Borrelia 
  • Leptospira 
Fenster schliessen

Where is endoflagella ?

  • characteristic ONLY in spirochetes 
  • under the phospholipid-rich outer membrane - protects from immune recognition 
  • in periplasm
Fenster schliessen

Endoflagella also known as ?

axial filament
Fenster schliessen

Function of axial filament 

  • rotation of flagella spins the spirochete around 
  • generates corkscrew type movement 
Fenster schliessen

Composition of flexible spiral bacteria from inner sheath to outer

  • innermost portion: cytoplasmic membrane 
  • 2nd layer: Cell Wall or periplasmic layer 
  • 3rd  : periplasmic space with endoflagella 
  • 4th: outer membrane - surrounding endoflagellla and protects from immune recognition
Fenster schliessen

Virulence factors of flexible spiral bacteria

  • Motility - active penetration into tissue 
  • low immunity - protect from immune recognition 
  • OMP - adhesion 
  • fibronectin-binding - anti-phagocytic 
  • hyaluronidase 
  • endothelial cells damage - inflammation 

 

 flexible spiral bacteria - spirochete - bacteria with endoflagella/axial filament