Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
Fichier Détails
| Cartes-fiches | 343 |
|---|---|
| Langue | English |
| Catégorie | Biologie |
| Niveau | Université |
| Crée / Actualisé | 28.11.2016 / 06.02.2020 |
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Ect-hyma gangrenosum caused by which non-fermentative bacteria ?
pseudomonas aeruginosa - due to elastase
Pseudomonas aeruginosa clinical presentation:
→BE PSEUDO Cool MEN
B – Burn & Wound infections
E – Endocarditis in IV drug abusers (IV= intravenous)
P- pneumonia in cystic fibrosis & immunocompremised
S- Sepsis caused by soft tissue, skin, UT & LRT infections
E- External malignant otitis media in diabetic patients
U- UTI
DO – diabetic osteo-chondritis (inflammation of bone&cartilage)
C- Corneal Infections (corneal ulcers)
MEN- Meningitis
Pseudomonas aeruginosa in cystic fibroses patients lead to which clinical presentation?
pneumonia
Pseudomonas aeruginos leads to External otits name its synonym?
swimmer's ear
Swimmer's ear/external otitis is caused by which bacteria?
pseudomonas aeruginosa
Pseudomonas aeruginosa Virulence Factors:
Elastase
Phospholipase C – is a hemolysin
Proteases
Exotoxin A,S,T
Pyo-cyanin– blue pigementation – catalyse production of H2O2&superoxide
Pyo-verdin– green pigmentation
Adhesins: pili, flagella,
CAPSULE– alginate is a mucoid exopolysaccharide forms capsule
LPS – endotoxin
Name all hospital-acquired gram-negative bacteria:
-> not part of natural flora
What sort of infection does Burkholderia cepacia primarily cause?
Primarily opportunistic infections = restricted to patients receiving broad-spectrum antibioticsthat suppress normal intestinal flora
Which two bacteria cause primarily opportunistic infections ?
Burkholderia cepacia
Pseudomonas aeruginosa
Burkholderia cepacia reservoir
ubiquitous in environment
in CF patients (cystic fibrosis)
Which patients are highly susceptible for infection with Burkholderia cepacia
cystic fibrose patients– pneumonia + bacteremia
patients with CGD – chronic granulomatous disease
Clinical presentation of Burkholderia cepacia:
pulmonary infections
bacteremia
UTI
Name the opportunistic infections that burkholderia cepacia can cause
Steno-tropho-monas malto-philia clinical presentation
→ leads to nosocomial infections = opportunitsic infections in hospitalized patients – hospital-acquired infections
USUALLY= Bacteremia & Pneumonia
Acine-to-bacter baumannii similar clincial presentation as pseudomonas aeruginosa:
→ opportunistic pathogens – hospital-acquired infections
- Pneumonia
- bacteremia
- UTI
- Burn-wound infections
- Eye infections
Leptospira has 2 species name them:
Leptospira interrogans - pathogenic species
Leptospira biflexa - saprophytes
Name non-flexible spiral bacteria
- helicobacter
- campylobacter
- vibrio
Name flexible spiral bacteria
- Treponema
- Borrelia
- Leptospira
Where is endoflagella ?
- characteristic ONLY in spirochetes
- under the phospholipid-rich outer membrane - protects from immune recognition
- in periplasm
Endoflagella also known as ?
axial filament
Function of axial filament
- rotation of flagella spins the spirochete around
- generates corkscrew type movement
Composition of flexible spiral bacteria from inner sheath to outer
- innermost portion: cytoplasmic membrane
- 2nd layer: Cell Wall or periplasmic layer
- 3rd : periplasmic space with endoflagella
- 4th: outer membrane - surrounding endoflagellla and protects from immune recognition
Virulence factors of flexible spiral bacteria
- Motility - active penetration into tissue
- low immunity - protect from immune recognition
- OMP - adhesion
- fibronectin-binding - anti-phagocytic
- hyaluronidase
- endothelial cells damage - inflammation
flexible spiral bacteria - spirochete - bacteria with endoflagella/axial filament
Leptospira reservoir
Leptospira transmission
Leptospira penetrate human through
- intact mucous membrane
- or scretched skin (abresions - schürfwunde)
- or conjunctiva
Leptospirosis can be
Leptospira interrogans causes a more severe illness of leptospir-osis
Most important species of Mycoplasma ?
Mycoplasma pneumonia - Eaton agent
Mycoplasma pneumoniae also named
Eaton agent
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