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Erstellt / Aktualisiert 06.05.2021 / 06.06.2021
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Fenster schliessen

Pro's Translational Approach of Research 

1. Physiological Mechanisms of energy balance regulation are well conserved

2. Methodology/Ethics

3. Control of variables like environment, genetic variation, placebo effects

4. Repeatability

5. cost

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Cons Translational Approach Research 

1. Mice are not rats and not humans 

2. moslty male animals are used 

 

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Measures of obesity 

1. WHR

2. BMI 

- widely used

- does not take the body composition into account -> great disadvantage

- however, correlations are still seen between BMI & health risks 

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Causes of obesity (2) 

1. Energy intake & energy expenditure 

2. Genetics & Environment 

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Energy expenditure (&energy intake) 

 

Brown Adipose tissue -> UPC1 (uncouples ATP to produce heath without using muscular activity) 

-> NO convincing evidence yet that BAT as viable pharmacological target for BW loss (activation through pharmacological might even lead to increased heart rate and systolic blood pressure) 

Beta-2 Adrenoceptor = main target for pharmaceuticals to target BAT 

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Does excess caloric intake lead to an activation of BAT as means of preventing obesity? 

NO! No evolutionary reason why such a mechanism should have been developed -> unnecessary energy waste 

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Energy expenditure (&energy intake) -> Thyroid hormones 

- cold environment & eating increase thyroid hormone secretion (they increase the metabolism in general) 

. Specifially increase heat production through an uncoupling effect: "endogenous uncouplers" 

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Genes & Environment 

Is obesity monogenetic? 

NO! Polygenic: independent & interacting effects of genetics, epigenetics & the environment 

(monogenic diseases in relation to bodyweight are mostly related to leptin deficiency - but only makes up 5% of obesity cases)