Set of flashcards Clinical Pharmacology

Flashcards	165
Language	English
Category	Medical
Level	University
Created / Updated	17.05.2020 / 14.06.2020
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During interpretation of child-pugh score, 8-9 points (liver dysfunction) requires dose reduction of liver-metabolised drugs by

A) 10%

B) 25%

C) 50%

D) 75%

A) 10%

B) 25%

C) 50%

D) 75%

Reduction (decreased surface) of gastrointestinal tract can cause:

A) increase of absorption of etambutol and chinidine

B) increase of elimination of propranolol

C) decrease of absorption of etambutol and chinidine

D) increase of distribution of paracetamol

A) increase of absorption of etambutol and chinidine

B) increase of elimination of propranolol

C) decrease of absorption of etambutol and chinidine

D) increase of distribution of paracetamol

Iatrogenic response (effect):

A) Response where a drug causes a disease-like state; for example antipsychotics can cause a Parkins

B) Rare adverse drug response resulting from a genetic predisposition; for exapmle, lack of drug metabolizing enzymes

C) Unwanted effects of drugs that appear at normal doses required for therapeutic response

D) Autoimmune reaction like a rash

A) Response where a drug causes a disease-like state; for example antipsychotics can cause a Parkins

B) Rare adverse drug response resulting from a genetic predisposition; for exapmle, lack of drug metabolizing enzymes

C) Unwanted effects of drugs that appear at normal doses required for therapeutic response

D) Autoimmune reaction like a rash

What drugs does alpha-1- acid glycopprotein bind?

A) acidic drugs

B) with long half-life

C) most basic

D) high molecular

A) acidic drugs

B) with long half-life

C) most basic

D) high molecular

This can reduce the efficacy of oral contraceptives and should not be used together:

A) Digoxin

B) Ketoconazole

C) Ciclosporin

D) Rifampicin

A) Digoxin

B) Ketoconazole

C) Ciclosporin

D) Rifampicin

ketoconazole and itraconazole are potent inhibitors of which P450?

A) 2C9

B) 2D6

C) 3A4

D) 2C18

A) 2C9

B) 2D6

C) 3A4

D) 2C18

In the mechanistic classification of adverse drug reactions, which of the following statements best describes type A (augmented):

A) Reactions who biological characteristics can be predicted based on chemical structure of the drug

B) Reaction predictable from the known pharmacology of the drug, usually dose-

C) Reaction not predictable from the known pharmacology of the drug, usually independent o fits primary biological effect

D) Reaction occurs many years after treatment following exposure to another drug

A) Reactions who biological characteristics can be predicted based on chemical structure of the drug

B) Reaction predictable from the known pharmacology of the drug, usually dose-

C) Reaction not predictable from the known pharmacology of the drug, usually independent o fits primary biological effect

D) Reaction occurs many years after treatment following exposure to another drug

what physiologic change associated with normal aging may affect Mr. Jones, 80 year old, clinical response to amiodarone?

s

A) Prolonged half-life of lipid-soluble drugs due to a higher relative composition of body fat compared to younger individual

B) Less water = lower volume of distribution

C) Lower serum proteins (like albumin) increase the concentrations of unbound (free

D) Slowed phase 1, cytochrome P450, reactions

A) Prolonged half-life of lipid-soluble drugs due to a higher relative composition of body fat compared to younger individual

B) Less water = lower volume of distribution

C) Lower serum proteins (like albumin) increase the concentrations of unbound (free

D) Slowed phase 1, cytochrome P450, reactions

Which type of pharmacoeconomic analysis uses Quality adjusted life years as an outcome?

A) Cost-benefit (CBA)

B) Cost-utility (CUA)

C) Cost-minimization (CMA)

D) Cost-effectiveness (CEA)

A) Cost-benefit (CBA)

B) Cost-utility (CUA)

C) Cost-minimization (CMA)

D) Cost-effectiveness (CEA)

A 36-year old female wishes to become pregnant with her second child. Her first child was born with spina bifida. Which of the following is the most appropriate folic acid recommendation for this patient:

A) Folic acid 4 mg orally daily starting at 10 weeks gestations

B) Folic acid 0.4 mg with a multivitamin orally daily starting 3 months before pregnancy

C) Folic acid 4 mg with a multivitamin orally daily starting 3 months before pregnancy

D) Not folic acid supplement is required

A) Folic acid 4 mg orally daily starting at 10 weeks gestations

B) Folic acid 0.4 mg with a multivitamin orally daily starting 3 months before pregnancy

C) Folic acid 4 mg with a multivitamin orally daily starting 3 months before pregnancy

D) Not folic acid supplement is required

Who is most at risk of developing adverse drug reactions?

A) A K, male, age 35, no further disease

B) B C, male age 55, hypertension, cataract, IBS

C) G C, female, age 87, taking insulin, metoprolol, inslapamide, ASA, Simvastatin,

D) A, b, c

A) A K, male, age 35, no further disease

B) B C, male age 55, hypertension, cataract, IBS

C) G C, female, age 87, taking insulin, metoprolol, inslapamide, ASA, Simvastatin,

D) A, b, c

Best formula for calculating the GFR for patients with severe renal deficiency?

A) Jellife equation

B) Cockroft and gualt equation

C) Modification of diet in renal disease (MDRD) formula

D) CKD-EPI (chronic kidney disease epidemiology collaboration)

A) Jellife equation

B) Cockroft and gualt equation

C) Modification of diet in renal disease (MDRD) formula

D) CKD-EPI (chronic kidney disease epidemiology collaboration)

Which of the following is not a side effect of the cholonireceptor blocker (Atropine)?

A) Increased pulse

B) Urinary retention

C) Constipation

D) Mydriasis

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

A) Increased pulse

B) Urinary retention

C) Constipation

D) Mydriasis

Which of the following is not a side effect of the diuretics (loop diuretics)?

A) Alkalosis

B) nausea

C) hypotension

D) potassium deficits

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

A) Alkalosis

B) nausea

C) hypotension

D) potassium deficits

Which is the most effective method of managing polypharmacy?

A) Use a brown-bag review of medications at each office visit, to ensure an ... med list

B) Limit your patients' medication list to no more than 4 medicines

C) Regularly assess patient adherence to the medication regimen

D) A and C

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

A) Use a brown-bag review of medications at each office visit, to ensure an ... med list

B) Limit your patients' medication list to no more than 4 medicines

C) Regularly assess patient adherence to the medication regimen

D) A and C

Theophylline levels increased with:

A) smoking

B) Phenytoin

C) Cimetidine

D) Magnesium

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

A) smoking

B) Phenytoin

C) Cimetidine

D) Magnesium

Which is the best example of polypharmacy?

A) Your patient is filling her medications at more than 1 drugstore

B) Your patient is taking more than 2 medications

C) Your patient is taking more than 9 medications

D) Your patient is taking a potentially inappropriate combination of medicine

A) Your patient is filling her medications at more than 1 drugstore

B) Your patient is taking more than 2 medications

C) Your patient is taking more than 9 medications

D) Your patient is taking a potentially inappropriate combination of medicine

Which of the following is NOT a side effect of the ACE inhibitor (Captopril)?

A) rash

B) angioedema

C) cough

D) congestion

A) rash

B) angioedema

C) cough

D) congestion

Which of the following is not an effect of the drug (Isoflurane)?

A) Elevated lipid levels

B) nausea

C) increased blood flow to the brain

D) decreased respiratory function

A) Elevated lipid levels

B) nausea

C) increased blood flow to the brain

D) decreased respiratory function

Which of the following is NOT true regarding the half-life of a drug?

A) A half-life can be decreased in patient with renal disease

B) half-life does not change throughout a patient's life

C) liver diseases can increase half-life

D) biological half-life determines the dosage range of the drug

A) A half-life can be decreased in patient with renal disease

B) half-life does not change throughout a patient's life

C) liver diseases can increase half-life

D) biological half-life determines the dosage range of the drug

Clinical Pharmacology

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