Katzung Test 4

Which statement about Nalbuphine is accurate?

(Katzung 11th and 12th)

Which drug does not activate opioid receptors, has been proposed as a

maintenance drug in treatment programs for opioid addicts, and with a single

oral dose, will block the effects of injected heroin for up to 48 h?

(Katzung 11th and 12th)

Which drug is a full agonist at opioid receptors with analgesic activity equivalent

to morphine, a longer duration of action, and fewer withdrawal signs on abrupt

discontinuance than morphine?

(Katzung 11th and 12th)

Your 37-year-old patient has been diagnosed with a rare metastatic carcinoid

tumor. This neoplasm is releasing serotonin, bradykinin, and several unknown

peptides. The effects of serotonin in this patient are most likely to include

(Katzung 11th and 12th)

A 23-year-old woman suffers from recurrent episodes of angioneurotic edema

with release of histamine and other mediators. Which of the following drugs is

the most effective physiologic antagonist of histamine in smooth muscle?

(Katzung 11th)

A 23-year-old woman is admitted to the emergency department with difficulty

breathing. Examination reveals significantly laryngeal edema. Past medical

history indicates that she suffers from recurrent episodes of angioneurotic

edema with release of histamine and other mediators. Which of the following

drugs is the most effective physiologic antagonist of histamine in smooth

muscle?

(Katzung 12th)

A 20-year-old woman is taking over-the-counter Diphenhydramine for severe

hay fever. Which of the following adverse effects is she most likely to report?

(Katzung 11th and 12th)

A laboratory study of new H2 blockers is planned. Which of the following will

result from blockade of H2 receptors?

(Katzung 11th and 12th)

You are asked to consult on a series of cases of drug toxicities. Which of the

following is a recognized adverse effect of Cimetidine?

(Katzung 11th)

An obese 40-year-old many (BMI 31) is being seen in the cardio-pulmonary clinic

for pulmonary hypertension and a cardiac murmur. He took Fenfluramine for

several years in an attempt to reduce his weight. The mechanism by which

Fenfluramine affected appetite is

(Katzung 12th)

A 40-year-old patient is about to undergo cancer chemotherapy with a highly

emetogenic (nausea- and vomiting-causing) drug combination. The antiemetic

drug most likely to be included in her regimen is

(Katzung 11th and 12th)

The hospital Pharmacy Committee is preparing a formulary for staff use. Which

of the following is a correct application of the drug mentioned?

(Katzung 11th and 12th)

A 26-year-old woman presents with amenorrhea and galactorrhea. Her prolactin

level is grossly elevated (200 ng/mL vs normal 20 ng/mL). Which of the following

is most useful in the treatment of hyperprolactinemia?

(Katzung 11th and 12th)

A 28-year-old office worker suffers from intense migraine headaches. Which of

the following is a serotonin agonist useful for aborting an acute migraine

headache?

(Katzung 11th and 12th)

A 33-year-old woman attempted to induce an abortion using ergotamine. She is

admitted to the emergency department with severe pain in both legs. On

examination, her legs are cold and pale with absent arterial pulses. Which of the

following is the most useful antidote for reversing severe ergot-induced

vasospasm?

(Katzung 11th and 12th)

A 19-year-old woman complains of severe dysmenorrhea. A uterine stimulant

derived from membrane lipid in the endometrium is

(Katzung 11th + 12th)

A 20-year-old woman suffers from absence seizures. Which of the following

statements about her proposed drug management is least accurate?

(Katzung 12th)

A 24-year old stockbrocker has developd a "nervous disposition". He is easily

startled, worries about inconsequential matters, and sometimes complains of

stomach cramps. At night he grinds his teeth in his sleep. There is no history of

drug abuse. Diagnosed as suffering from generalized anxiety disorider he is

prescribed Buspirone. The patient should be informed to anticipate

A 35-year-old woman with moderately severe arthritis has been treated with

nonsteroidal anti-inflammatory drugs for 6 mo. Her arthritis symptoms have

been well controlled. She now complains of heartburn and indigestion. A fecal

blood test is positive. You give her a prescription for a drug to be taken along

with the anti-inflammatory agent, but 2 d later she calls the office complaining

that your last prescription has caused severe diarrhea and cramping that

resembles her periods. Which of the following is most likely to be associated

with increased gastrointestinal motility and uterine cramping?

(Katzung 12th)

A 40-year-old woman has sporadic attacks of intense anxiety with marked

physical symptoms, including hyperventilation, tachycardia, and sweating. If she

is diagnosed as suffering from a panic disorder, the most appropriate drug to

use is

(Katzung 11th and 12th)

A 43-year-old very overweight man complains of not sleeping well and feeling

tired during the day. He says that his wife is the cause of the problem because

she wakes him up several times during the night because of his loud snores.

This appears to be a breathing-related sleep disorder, so you should probably

write a prescription for

(Katzung 12th)

A 45-year-old very overweight man complains of not sleeping well and feeling

tired during the day. He says that his wife is the cause of the problem because

she wakes him up several times during the night because of his loud snores.

This appears to be a breathing-related sleep disorder, so you should probably

write a prescription for

(Katzung 11th)

A 50-year-old woman with moderately severe arthritis has been treated with

nonsteroidal anti-inflammatory drugs for 6 mo. She now complains of heartburn

and indigestion. You give her a prescription for a drug to be taken along with

the anti-inflammatory agent, but 2 d later she calls the office com- plaining that

your last prescription has caused severe diarrhea. Which of the following is most

likely to be associated with increased gastrointestinal motility and diarrhea?

(Katzung 11th)

A 51-year-old patient with parkinsonism is being maintained on

levodopa-carbidopa with adjunctive use of low doses of Tolcapone but continues

to have off-periods of alkinesia. The most appropriate drug to “rescue” the

patient but that will only provide temporary relief is

(Katzung 12th)

A 57-year-old man has severe pulmonary hypertension and right ventricular

hypertrophy. Which of the following agents causes vasodilation and may be

useful in pulmonary hypertension?

(Katzung 11th)

A 9-year-old child is having learning difficulties at school. He has brief lapses of

awareness with eyelid fluttering that occur every 5–10 min.

Electroencephalogram (EEG) stud- ies reveal brief 3-Hz spike and wave

discharges appearing synchronously in all leads. Which drug would be effective

in this child without the disadvantages of excessive sedation or tolerance

development?

(Katzung)

A newborn infant is diagnosed with transposition of the great vessels, wherein

the aorta exits from the right ventricle and the pulmonary artery from the left

ventricle. Which of the following drugs is likely to be used in preparation for

surgical correction of this anomaly?

(Katzung 11th + 12th)

A patient with a bleeding tendency presents in the hema- tology clinic. He is

apparently taking large amounts of an unidentified drug that inhibits platelet

activity. Which of the following is taken orally and directly and reversibly inhibits

platelet cyclooxygenase?

(Katzung 11th + 12th)

A patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam

or oxazepam can be used for preanesthetic sedation in this patient without

special concern regarding excessive CNS depression because these drugs are

(Katzung 11th and 12th)