immuno

Cellular and molecular immunology

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Flashcards	9
Language	English
Category	Biology
Level	University
Created / Updated	21.09.2017 / 24.05.2018
Weblink	https://card2brain.ch/box/20170921_immuno
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CD45, CD14

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Monozyte

CD45, CD3

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T Lymphozyte, CD8 cytotoxic T cell, CD4 T helper cell

CD45, CD19

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B Lymphocyte

primary lymphoid organs and function

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Bone marrow and thymus:

development of immature blood cells
diffeentation, proliferation and maturation of stem cells into immunocompetent cells

secondary lymphoid organs and function

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Lymph Nodes
Tonsils
Spleen
Maintenance of naive lymphocytes
initiate adaptiv immune response

Two different functional state of dendritic cells

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immature and mature DC

Immature: act as sensors of the environment

Mature: upon stimulation, migrate to secondary lymphoid organs ans stimulate naive T cells, leading to activation of T cells, B cells and Macrophages

Immature dendritic cells are specialized in and express what?

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Antigen uptake and processing

specialized in endocytosis (antigen uptake)
Express low level of MHC I and II
Short half live of MHC on surface
Rich in vesicles with lysosomal markers that are full of MHC II
Express low level of co-stimulatory molecules
Located: blood lymphoid and non-lymphoid tissue (skin and mukosa)

APC - ?

MHCII - ?

DC40 - ?

B7-1 (CD80) - ?

B7-2 (CD86) - ?

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APC - T cell

MHCII - T cell receptor

DC40 - CD40L (CD154)

B7-1 (CD80) - CD28

B7-2 (CD86) - CTLA-4

The three signals required for DC maturation

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specifity/antigen
co-stimulation (CD28-B7)
polarization/cytokines

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