immuno
Cellular and molecular immunology
Cellular and molecular immunology
Kartei Details
| Karten | 9 |
|---|---|
| Sprache | English |
| Kategorie | Biologie |
| Stufe | Universität |
| Erstellt / Aktualisiert | 21.09.2017 / 24.05.2018 |
| Lizenzierung | Keine Angabe |
| Weblink |
https://card2brain.ch/box/20170921_immuno
|
| Einbinden |
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CD45, CD14
Monozyte
CD45, CD3
T Lymphozyte, CD8 cytotoxic T cell, CD4 T helper cell
CD45, CD19
B Lymphocyte
primary lymphoid organs and function
Bone marrow and thymus:
- development of immature blood cells
- diffeentation, proliferation and maturation of stem cells into immunocompetent cells
secondary lymphoid organs and function
- Lymph Nodes
- Tonsils
- Spleen
- Maintenance of naive lymphocytes
- initiate adaptiv immune response
Two different functional state of dendritic cells
immature and mature DC
Immature: act as sensors of the environment
Mature: upon stimulation, migrate to secondary lymphoid organs ans stimulate naive T cells, leading to activation of T cells, B cells and Macrophages
Immature dendritic cells are specialized in and express what?
Antigen uptake and processing
- specialized in endocytosis (antigen uptake)
- Express low level of MHC I and II
- Short half live of MHC on surface
- Rich in vesicles with lysosomal markers that are full of MHC II
- Express low level of co-stimulatory molecules
- Located: blood lymphoid and non-lymphoid tissue (skin and mukosa)
APC - ?
MHCII - ?
DC40 - ?
B7-1 (CD80) - ?
B7-2 (CD86) - ?
APC - T cell
MHCII - T cell receptor
DC40 - CD40L (CD154)
B7-1 (CD80) - CD28
B7-2 (CD86) - CTLA-4
