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Microbiology TEST 2

Lectures 5 - 7

Lectures 5 - 7

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Karten 343
Sprache English
Kategorie Biologie
Stufe Universität
Erstellt / Aktualisiert 28.11.2016 / 06.02.2020
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Bordetella pertussis vaccination DTP name its components:

DTP - whole-cell vaccine components 

  • fimbria 
  • other toxins 
  • pertussis toxin
  • endotoxin
  • FHA - filamentous hemag-glutinin 
  • pertactin 

Bordetella pertussis vaccination DTaP name its components:

 

acellular vaccine components:

  • fimbria 
  • pertactin 
  • FHA - filamentous hemag-glutinin 
  • INACTIVATED pertussis toxin 

Vaccination recommended for adults against Bordetella Pertussis is named and used what for ?

  • Tdap 
  • to boost waning immunity
  • adults aged 19-64

Name two bacteria that appaer under microscope as diplococci:

Name bacteria that are strict aerobic gram-negative:

Name bacteria that are oxidase-positive:

Haemophilae are 

Haemophilae influenzae reservoir: 

haemophilus influenzae transmission

 

Name pathogenic species (diseases causing) of Haemophilae: 

 

Haemophilus can be endogenous and exogenous!!!

  • Haemophilus influenzae - exogenous/endogenous
  • Haemophilus aegyp-tius -endogenous
  • Haemophilus du-cre-yi  -endogenous 
  • Haemophilus parainfluenzae - in mouth - endogenous

Haemophilus aegyp-tius clinical presentation: 

 

Rather OPPORTUNISTIC infections than pathogenic!! ENDOGENOUS 

Haemophilus du-cre-yi clinical presentation: 

  • sexually transmitted 
  • soft chancre 
  • chanc-roid 

In der Regel erkennt man sie an sehr schmerzhaften, kleinen Hautgeschwüren (Ulcera) an den Geschlechtsorganen.

Also Known as Ulcus Molle

Haemophilus infuelnzae has a 

polysaccharide capsule ( serotypes a-f)

Since the vaccination against Haemophilius influenzae polysaccharide capsule for serotype 1, ______, which was the most diseases causing serotype. 

Now more than half of all INVASIVE disease is caused by 2.  ___________ strains.

  1. serotype B
  2. nonencapsulated strains

Haemophilus influenzae nonencapsulated strains clinical presentation: 

Haemophilus influenzae nonencapsulated strains & Haemophilus parainfluenzae colonize in first few months of life the 1_______ and therefore causes 2.__________ infections, rather than disseminated infections. 

  1. colonize the upper respiratory tract 
  2. localized infections = otitis media, sinusitis, bronchitis, penumonia 

Most common cause of ENCAPSULATED Haemophilius influenzae infection is in: 

 

invasive serotype = B 

unvaccinated children

Encapsulated Haemophilus Influenzae clinical presentation in unvaccinated children: 

Which type of Haemophilus influenzae is the INVASIVE DISEASE causing bacteria? 

Which type of Haemophilus influenzae is the NON-invasive disease causing bacteria? 

Name the non-invasive RTI (respiratory tract infections) caused by unencapsulated Haemophilus influenzae 

 

 

Haemophilus influenzae virulence factors: 

  1. pili and adhesins - mediate coloniation to oropharynx
  2. LPS - leading to damage of respiratory epithelium & can enter blood if capsulated 
  3. POLYSACCHARIDE CAPSULE - leading to dissemination 
  4. IgA1 protease - facilitate colonization 

Haemophilus Influenzae encapsulated form has a polysaccharide capsule with a specific name: 

PRP - poly-ribitol phosphate 

  • risk group - infants aged 6 to 4 years - lack of specific antibodies 
  •  patients with complement deficiency
  •  patienst undergone splen-ectomy

Encapsulated (type b) Haemophilus influenzae prevention: 

Hib vaccination: 

  1. vaccine composed of capsule (PRP) polysaccharide CONJUGATED with protein (mutant diphteria toxin protein) 

Which of the Haemophilae is also named Koch-Weeks bacillus ? 

Haemophilus aegyp-tius

Haemophilus aegyp-tius has a second name: 

Koch-Weeks bacillus

Encapsulated (type b) Haemophilus Influenzae leads to: 

Name opportunistic pathogens of Haemophilae:

Haemophilus parainfluenzae can not only cause local infection but also ? 

endocarditis

Name Bacteria of Yersinia genus:

Yersinia pestis 

Yersinia pseudo-tuberculosis 

Yersinia entero-coli-tica

Yersinia pestis clinical presentation:

  1. plague – bubonic plague – „black death“ - (boubon = greek means groin) 
  2. pneumonic plague
  3. septicemic plague

 

Yersinia pestis prevents phagosome-lysosome fusion why ?

It is FACULTATIVE intracellular pathogen

Yersinia pestis transmission:

ZOONOSIS

1. human to human by air-borne route = pneumonic plague 

2. Vectors = bitten by infected fleas 

3. Direct contact = by touching dead rodents

Yersinia pestis reservoir:

Rats – rodents wild= nagetiere = URBAN plague 

Squirrels = SYLVATIC plague

What is sylvatic plague in yersinia pestis?

Is the plague caused in Squirrels

Yersinia pestis virulence factors:

Facultative intracellular organism 

1. Fraction 1 (F1) – capsular antigen is antiphagocytic 

2. V & W antigen 

3. Toxin = pesticin 

4. Capsule

Yersinia pestis staining:

bipolar staining – the ends of coccobacillus stain stronger than the center

Yersinis pestis clinical presentation of bubonic plague:

SYSTEMIC SPREAD via bloodstream to liver, lungs etc. = SEPSIS 

hemorrhages under skin causes blackish discoloration =black death 

75% die if untreated

Bubonic plague caused by Yersinia pestis can lead to?

Septicemic plague – endotoxin responsible

Which Bacteria causes the so called „Black Death“

Yersinia pestis – bubonic plague -transmitted by vectors (fleas)

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