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Risk of transmission of neoplastic disease - Chris Watson

Six months after transplantation the recipient of the left kidney is identified as having a donor derived cancer. It transpires that the donor cancer has spread to all the recipients of organs from the same donor. Which recipient is likely to have the best prognosis?

The recipient of the heart

The recipient of the left lung

The recipient of the liver

The recipient of the right kidney

The recipient of the right lung

Tissue Donation (Cornea / Homocraft) – Jacinto Sanchez Ibanez

Which of the following situations the deceased is elegible as tissue donor:

Any antecedent of malignancy is an absolute contraindication for tissue donors

Primary basal cell carcinoma is a contraindication

The risk is the same as with organ donors

None of them

Tissue Donation (Cornea / Homocraft) – Jacinto Sanchez Ibanez

In the evaluation of tissue donor, the following steps are mandatory:

Medical and social history

Physical exam

Calculation of Hemodilution

All of them

Tissue Donation (Cornea / Homocraft) – Jacinto Sanchez Ibanez

Which one is an absolute contraindication for cornea donors:

Donor age less than 75 years old

History of previous ocular surgery

Bacterial septicemia

Leukemia

Tissue Donation (Cornea / Homocraft) – Jacinto Sanchez Ibanez

In the case of cornea grafts:

Because it is vascularized graft the risk of transmission is higher

Age donor is enough to determine the viability of the tissue

The previous antecedent of herpes infection in one eye contra indicates both corneas

All of them are false

Tissue Donation (Cornea / Homocraft) – Jacinto Sanchez Ibanez

In the case of cardiovascular grafts (choose the correct statement):

There is no age limit

CPR does not contraindicate heart valve donation

Marfan’s syndrome is a contraindication

All of them

Biovigilance in organ and tissue donation and transplantation – Inês Ushiro-Lumb

In relation to an unexpected event in a recipient of a solid organ transplant, the local transplant unit should:

Complete all investigations linking the donor as the source of disease transmission before reporting it to the biovigilance team

Contact other transplant centres directly in order to avoid delays

Obtain donor information from the donor hospital

Initiate prompt investigation and management of their patient and alert the biovigilance team

Biovigilance in organ and tissue donation and transplantation – Inês Ushiro-Lumb

Which statements below are correct in relation to biovigilance systems

They are programs that must be set up independently from quality management systems due to their complex nature

Co-ordination should be carried out by trained professionals within an appointed team

Whereas SAR must be reported promptly, SAE can be dealt with by the transplant unit as the recipient has not come to harm

Certain clinical conditions require rapid escalation of communication , which could be done through a rapid alert system

Biovigilance in organ and tissue donation and transplantation – Inês Ushiro-Lumb

The detection and communication of SAREs to the appropriate Biovigilance team

Is primarily and exclusively the responsibility of the patient ‘s responsible doctor

Applies to the immediate post-transplant period, as all untoward events should present within this time frame

May require high level of suspicion and understanding of the specific medi-cal condition in order to be linked to the transplant process

Time from transplant to recognition of SARE determines how urgent it has to be reported

Biovigilance in organ and tissue donation and transplantation – Inês Ushiro-Lumb

Please indicate which statements are incorrect:

It is a powerful tool to safeguard health professionals, donors and patients

The production and dissemination of an incident report is optional, depend-ing on the impact level of the SARE

Despite biovigilance teams training, expert advice is often required in SARE investigations

Biovigilance programs serve exclusively the needs of the regulatory authori-ties

«Meet the international experts»

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