Clinical Pharmacology

TPMT is responsible for the metabolism of?

To antimicrobial efficacy - concentration dependent. (pattern of bacterial killing) correlated with AUC/MIC, Peak/MIC belong the following group of antibiotics

Which of the following are enzyme inhibitors?

The first-pass effect:

The persistent inhibition of bacterial growth after antibiotic elimination from the body is called:

The goal of therapeutic drug monitoring of methotrexate is:

At what time the notification of severe adverse drug reaction is made:

The recommended comparator in pharmacoeconomic analysis is:

The most frequently observed adverse events in short time use of biological drugs should not be:

Do indomethacin can be given with paracetamol:

During the use of oral antidiabetic drugs may lead to hyperglycemia, if the patient also uses:

In organ transplant patients statin of choice should be:

The change in the bioavailability of drugs substantially undergoing the first-pass effect in the elderly is the result of:

In order to avoid harmful consequences associated with impaired excretion of the drug substance in a renal disease, the following dosages of drugs:

The indication of therapeutic drug monitoring of aminoglycoside antibiotics should not be:

The combined use of ketoconazole and erythromycin may: (1 point)

171) Which of the following statements is correct?
Antihistamine agents used for allergicrhinitis have antagonistic activity against both H1 and H2 receptors:

Possible risks for patient taking part in clinical trial

Genetically targeted therapy monitored concentration of the drug in the body can be used for medical treatment:

Fast increasing the dose of methadone or administration of a high dose can cause:

Among the NSAIDs in the elderly is desirable to use:

During the treatment of the elderly should be avoided:

A person being ultra-fast metabolism (carrier 5 copies of the gene CYP2D6) were treated with a tricyclic antidepressant. It is necessary to dose:

Among analgesics most commonly causes damage to the bone:

A significant increase in plasma digoxin concentration may result in combined therapy with:

Increased risk of depression in the elderly may be associated with the use of:

Inadvisable and inconsistent with the principles of optimizing the use of analgesics is pairing:

Poor CYP2D6 phenotype of oxidation can cause:

Drug metabolism may be affected

Factors which can increase the fraction of unbound drug

During interpretation of child-pugh score, 8-9 points (liver dysfunction) requires dose reduction of liver-metabolised drugs by

Reduction (decreased surface) of gastrointestinal tract can cause:

Iatrogenic response (effect):

What drugs does alpha-1- acid glycopprotein bind?

This can reduce the efficacy of oral contraceptives and should not be used together:

ketoconazole and itraconazole are potent inhibitors of which P450?

In the mechanistic classification of adverse drug reactions, which of the following statements best describes type A (augmented):

Who must report ADR:

what physiologic change associated with normal aging may affect Mr. Jones, 80 year old, clinical response to amiodarone?

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Which type of pharmacoeconomic analysis uses Quality adjusted life years as an outcome?