Katzung Test 4

A 17-year-old patient complains that he develops wheezing and severe

shortness of breath whenever he takes aspirin for headache. Increased levels of

which of the following may be responsible, in part, for some cases of aspirin

hypersensitivity?

(Katzung 11th + 12th)

A 19-year-old woman complains of severe dysmenorrhea. A uterine stimulant

derived from membrane lipid in the endometrium is

(Katzung 11th + 12th)

A 20-year-old woman suffers from absence seizures. Which of the following

statements about her proposed drug management is least accurate?

(Katzung 12th)

A 24-year old stockbrocker has developd a "nervous disposition". He is easily

startled, worries about inconsequential matters, and sometimes complains of

stomach cramps. At night he grinds his teeth in his sleep. There is no history of

drug abuse. Diagnosed as suffering from generalized anxiety disorider he is

prescribed Buspirone. The patient should be informed to anticipate

A 35-year-old woman with moderately severe arthritis has been treated with

nonsteroidal anti-inflammatory drugs for 6 mo. Her arthritis symptoms have

been well controlled. She now complains of heartburn and indigestion. A fecal

blood test is positive. You give her a prescription for a drug to be taken along

with the anti-inflammatory agent, but 2 d later she calls the office complaining

that your last prescription has caused severe diarrhea and cramping that

resembles her periods. Which of the following is most likely to be associated

with increased gastrointestinal motility and uterine cramping?

(Katzung 12th)

A 40-year-old woman has sporadic attacks of intense anxiety with marked

physical symptoms, including hyperventilation, tachycardia, and sweating. If she

is diagnosed as suffering from a panic disorder, the most appropriate drug to

use is

(Katzung 11th and 12th)

A 43-year-old very overweight man complains of not sleeping well and feeling

tired during the day. He says that his wife is the cause of the problem because

she wakes him up several times during the night because of his loud snores.

This appears to be a breathing-related sleep disorder, so you should probably

write a prescription for

(Katzung 12th)

A 45-year-old very overweight man complains of not sleeping well and feeling

tired during the day. He says that his wife is the cause of the problem because

she wakes him up several times during the night because of his loud snores.

This appears to be a breathing-related sleep disorder, so you should probably

write a prescription for

(Katzung 11th)

A 50-year-old woman with moderately severe arthritis has been treated with

nonsteroidal anti-inflammatory drugs for 6 mo. She now complains of heartburn

and indigestion. You give her a prescription for a drug to be taken along with

the anti-inflammatory agent, but 2 d later she calls the office com- plaining that

your last prescription has caused severe diarrhea. Which of the following is most

likely to be associated with increased gastrointestinal motility and diarrhea?

(Katzung 11th)

A 51-year-old patient with parkinsonism is being maintained on

levodopa-carbidopa with adjunctive use of low doses of Tolcapone but continues

to have off-periods of alkinesia. The most appropriate drug to “rescue” the

patient but that will only provide temporary relief is

(Katzung 12th)

A 57-year-old man has severe pulmonary hypertension and right ventricular

hypertrophy. Which of the following agents causes vasodilation and may be

useful in pulmonary hypertension?

(Katzung 11th)

A 9-year-old child is having learning difficulties at school. He has brief lapses of

awareness with eyelid fluttering that occur every 5–10 min.

Electroencephalogram (EEG) stud- ies reveal brief 3-Hz spike and wave

discharges appearing synchronously in all leads. Which drug would be effective

in this child without the disadvantages of excessive sedation or tolerance

development?

(Katzung)

A newborn infant is diagnosed with transposition of the great vessels, wherein

the aorta exits from the right ventricle and the pulmonary artery from the left

ventricle. Which of the following drugs is likely to be used in preparation for

surgical correction of this anomaly?

(Katzung 11th + 12th)

A patient with a bleeding tendency presents in the hema- tology clinic. He is

apparently taking large amounts of an unidentified drug that inhibits platelet

activity. Which of the following is taken orally and directly and reversibly inhibits

platelet cyclooxygenase?

(Katzung 11th + 12th)

A patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam

or oxazepam can be used for preanesthetic sedation in this patient without

special concern regarding excessive CNS depression because these drugs are

(Katzung 11th and 12th)

A patient with parkinsonism is being treated with levodopa. He suffers from

irregular, involuntary muscle jerks that affect the proximal muscles of the limbs.

Which of the following statements about these symptoms is accurate?

(Katzung 12th)

A previously healthy 40-year-old woman begins to suffer from slowed

mentation, lack of coordination, and brief writhing movements of her hands that

are not rhythmic. In addition, she has delusions of being persecuted. The

woman has no history of psychiatric or neurologic disorders. Although further

diagnostic assessment should be made, it is very likely that the most

appropriate drug for treatment will be

(Katzung 12th)

A young female patient suffers from absence seizures. Which of the following

statements about her proposed drug management is NOT accurate?

(Katzung 11th)

A young male patient suffers from a seizure disorder charac- terized by tonic

rigidity of the extremities followed in 15–30 s of tremor progressing to massive

jerking of the body. This clonic phase lasts for 1 or 2 min, leaving the patient in a

stuporous state. Of the following drugs, which is most suitable for long- term

management of this patient?

(Katzung)

Abrupt withdrawal of antiseizure drugs can result in increases in seizure

frequency and severity. Withdrawal is most easily accomplished if the patient is

treated with

(Katzung)

An 82-year-old woman, otherwise healthy for her age, has difficulty sleeping.

Triazolam is prescribed for her at one half of the conventional adult dose. Which

statement about the use of triazolam in this elderly patient is accurate?

(Katzung 11th and 12th)

Bradykinesia has made drug treatment necessary in a 60-year-old male patient

with Parkinson's disease, and therapy is to be initiated with Levodopa

Regarding the anticipated actions of Levodopa, the patient need NOT be

informed that

(Katzung 12th)

Bradykinesia has made drug treatment necessary in a 60-year-old male patient

with Parkinson's disease, and therapy is to be initiated with Levodopa

The prescribing physician will (or should) know that Levodopa

(Katzung 12th)

Concerning the drugs used in parkinsonism, which statement is accurate?

(Katzung 12th)

Flumazenil will counteract the action of each of the following drugs

EXCEPT

(Katzung 12th)

Inflammation is a complex tissue reaction that includes the release of cytokines,

leukotrienes, prostaglandins and peptides. Leukotrienes involved in

inflammatory processes are typically produced from arachidonic acid by which

of the following enzymes?

(Katzung 12th)

Inflammation is a complex tissue reaction that includes the release of cytokines,

leukotrienes, prostaglandins, and pep- tides. Prostaglandins involved in

inflammatory processes are typically produced from arachidonic acid by which

of the following enzymes?

(Katzung 11th)

The mechanism of antiseizure activity of Carbamazepine is

(Katzung)

This drug is used in the management of insomnia and facilitates the inhibitory

actions of GABA, but is lacks anticonvulsant or muscle-relaxing properties and

has minimal effect on REM sleep. Its actions are antagonized by Flumazenil

(Katzung 12th)

Tolcapone may be of value in patients being treated with levodopa-carbidopa

because it

(Katzung 12th)

Which drug used in management of seizure disorders is most likely to elevate

the plasma concentration of other drugs administered concomitantly?

(Katzung)

Which drug used in the maintenance treatment of patients with tonic-clonic or

partial seizure states increases the hepatic metabolism of many drugs including

both phenytoin and warfarin?

(Katzung 11th and 12th)

Which mechanism explains Aspirin's inhibition of thromboxane synthesis?

(Katzung 12th)

Which of the following best describes the mechanism of action of

Benzodiazepines?

(Katzung 11th and 12th)

Which of the following drugs inhibits thromboxane synthesis much more

effectively than prostacyclin synthesis?

(Katzung 11th)

Which of the following drugs is most suitable for management of essential

tremor in a patient who has pulmonary disease?

(Katzung 12th)

Which of the following is a component of slow-reacting substance of anaphylaxis

(SRS-A)?

(Katzung 11th + 12th)

Which of the following is a leukotriene receptor blocker?

(Katzung 11th + 12th)

Which statement about Phenytoin is accurate?

(Katzung)

Which statement about Pramipexole is most accurate?

(Katzung 12th)