Pyrexia

Mindestens zwei Quellen inkl. Sputum und Urin

im Urin >10⁵ Kolonien

Candida endophthalmitis, oesophagitis, suppurative thrombophlebitis or wound infections/peritonitis ('open abdomen') may be the source of invasive Candida infections

• Pulmonary aspiration
• Postoperative fever (<48h)
• Trauma/haematoma
• Thromboembolism
• Gastrointestinal bleeding
• Drug-induced fever
• Febrile non-haemolytic red cell and platelet transfusion reactions
• Alcohol withdrawal
• Neuroleptic malignant syndrome
• Cerebral disease, including subarachnoid haemorrhage
• Gout
• Transplant rejection
• Neoplasia, including lymphoma
• Haematoma
• Myocardial infarction
• Addisonian crisis, acute adrenocortical insufficiency
• Acute pancreatitis

Clinical pulmonary infection score

Clinical pulmonary infection score

I    Three or more of the following:
a) Rectal temperature >38.0 °C or <35.5 °C
b) Leukocytes (<10.0 x 10⁹ /L) and/or left shift or leukopoenia (<3.0 x 10⁹/L)
c) >10 leukocytes per high power field in Gram stain of tracheal aspirate 
d) Positive (qualitative) culture of tracheal aspirate 

AND
II    New, persistent or progressive infiltrate on chest radiograph

AND
III    One or more of the following
a) Positive quantitative culture of bronchoalveolar lavage fluid (>10⁴cfu/mL) or PSB (>10³ cfu/L) or >5% of leukocytes containing phagocytosed bacteria.
b) Positive blood culture with the same micro-organism as that present in the airway
c) Positive culture of pleural fluid

• There is fever or a positive blood culture in the absence of another evident source of infection
• The CVC dwell time exceeds 3 days
• Fever abates after catheter removal
• There are signs of local (exit-site) infection.

Exit-site catheter infection is defined as the presence of positive quantitative catheter culture in the presence of symptoms of local infection (erythema, tenderness, induration, or purulence), in the absence of other foci.

Catheter-related blood stream infection (CRBSI) is diagnosed when the same organism is isolated (at higher concentrations – see below) on quantitative culture of the distal catheter segment and from the blood of a patient with clinical symptoms of local or systemic infection and no other source of infection evident.