Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Lernkarten
Escheri-chia Coli causing EXTRA-INTESTINAL DISEASE is the commensal pathobionts or the pathogenic form?
Commensal pathobionts
Name the EXTRA-intestinal diseases caused by E.coli:
- UTIs
- Infant meningitis
- Septicemia
Name the specific name of strains of E.coli that cause UTIs & Virulence Factors:
Uro-pathogenic strains
VF: Hemolysin & adhesins (P pili, Dr, AAF)
80% off all community-acquired UTIs are caused by which Entero-bacteria-ceae?
Escheri-chia coli uro-pathogenic strains
Neonatal meningitis appearing in infants age <1 month caused by which Entero-bacteria-ceae?
E.coli K1 capsulated strains
Neonatal meningitis caused by E.coli possess a specific antigen-name it:
K1 capsular antigen
In immunocompremised & hospitalized patients E.coli can lead to a specific extra-intestinal disease name it:
Septicemia – spread from urinary or GI tract
Name species of Salmonella
Salmonella typhi
Salmonella enterica
Name reservoir of Salmonella typhi & Salmonella paratyphi:
Only Humans
Name reservoir of other Salmonella serotypes other than typhi/paratyphi:
animals
Salmonella typhi & Salmonella paratyphi can survive at a specific site in Human body and cause what sort of carriage?
Survive in gallblader
establish chronic carriage
→ facultative intracellular
Salmonella transmission:
ingestion – food-borne
direct fecal-oral spread in children
Salmonella typhi transmission:
human-to-human spread = fecal-oral
Name Virulence Factors of Salmonella:
Enterotoxin
Cytotoxin
LPS
Vi capsule – antiphagocytic
Fimbria & Flagella(H-antigen)
Name the Salmonella clinical presentation:
1. Gastroenteritis/salmonellosis -nonbloody diarrhea
2. Septicemia – risk group immunocompromised, pediatric & geriatric patients
3. Enteric Fever = typhoid fever
4. Asymptomatic Colonization -chronic carriage/chronic colonization
Give a different name for gastroenteritis caused by nontyphoidal Salomnella
salmonellosis – due to enterotoxin
Enteric Fever caused by what species of Salmonella and name the other clinical name for enteric fever?
Salmonella typhi & Salmonella paratyphi
enteric fever = typhoid fever
Which bacteria causes typhoid fever?
Salmonella typhi & paratyphi
Other name for enteric fever?
Typhoid fever
Other name for typhoid fever?
enteric fever
Chronic colonalization of Salmonella typhi & paratyphi has what sort of clinical presentation:
Asymptomatic Colonization in the gallbladder
Name medical important species of shigella:
Shigella dysenteriae – most serious
Shigella flex-neri – most common in underdeveloped countries
Shigella sonnei – most common in developed countries
Which shigella species produces SHIGA toxin:
Shigella reservoir:
Shigella transmission
person-to-person by fecal-oral route- contaminated hands & less common food
Shigella is 1.________ & is spread from 2.__________ which protects them from host immunity.
invasive – Virulence Factor= invasins
cell-to-cell
Shigella is NOT spread through______?
Bloodstream
Which serotype of Shigella dys-en-teriae produces shiga toxin?
Sh. dys-en-teriae type 1
Which toxins have Sh. Flex-neri & Sh. Sonnei ?
Enterotoxin
Endotoxin
Shigella clinical presentation:
shigellosis – watery diarrhea, bloody stool
Shigellosis the complication:
HUS – hemolytic uremic syndrome
→ like EHEC/STEC & also caused by shiga toxin!
Name all glucose-fermentative bacteria:
Name all obligate ANAerobic gram-negative bacteria:
Name the most important genus of Bacteroides:
Bacteroides fragilis
What stimulates the growth of bacteroides ?
bile
Which obligate anaerobic gram-negative bacteria have a polysaccharide capsule?
bacteroides fragilis
prevotella melanino-genica
Name major virulence factor of Bacteroides fragilis:
polysaccharide capsule
enterotoxin B. Fragilis (LT zinc metalloprotease toxin) – diarrhea
→ no endotoxin – as LPS misses lipid A
Obligate Anaerobic gram-negative bacteria RESERVOIR:
virutally any anatomical site: mucosal surfaces of oropharynx, GI & genitourinary tract
(book says no skin, PPP says skin)
Obligate Anaerobic gram-negative bacteria cause endogenous or exogenous infection?
Endogenous Infections – as they are part of the natural flora of virtually any anatomical site
Predisposing factors leading to endogenous infection in obligate anaerobic gram-negative bacteria:
trauma, surgery, tissue necrosis, tissue ischemia
