Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Cartes-fiches
Bordetella pertussis vaccination DTP name its components:
DTP - whole-cell vaccine components
- fimbria
- other toxins
- pertussis toxin
- endotoxin
- FHA - filamentous hemag-glutinin
- pertactin
Bordetella pertussis vaccination DTaP name its components:
acellular vaccine components:
- fimbria
- pertactin
- FHA - filamentous hemag-glutinin
- INACTIVATED pertussis toxin
Vaccination recommended for adults against Bordetella Pertussis is named and used what for ?
- Tdap
- to boost waning immunity
- adults aged 19-64
Name two bacteria that appaer under microscope as diplococci:
Name bacteria that are strict aerobic gram-negative:
Name bacteria that are oxidase-positive:
Haemophilae are
Haemophilae influenzae reservoir:
haemophilus influenzae transmission
Name pathogenic species (diseases causing) of Haemophilae:
Haemophilus can be endogenous and exogenous!!!
- Haemophilus influenzae - exogenous/endogenous
- Haemophilus aegyp-tius -endogenous
- Haemophilus du-cre-yi -endogenous
- Haemophilus parainfluenzae - in mouth - endogenous
Haemophilus aegyp-tius clinical presentation:
Rather OPPORTUNISTIC infections than pathogenic!! ENDOGENOUS
Haemophilus du-cre-yi clinical presentation:
- sexually transmitted
- soft chancre
- chanc-roid
In der Regel erkennt man sie an sehr schmerzhaften, kleinen Hautgeschwüren (Ulcera) an den Geschlechtsorganen.
Also Known as Ulcus Molle
Haemophilus infuelnzae has a
polysaccharide capsule ( serotypes a-f)
Since the vaccination against Haemophilius influenzae polysaccharide capsule for serotype 1, ______, which was the most diseases causing serotype.
Now more than half of all INVASIVE disease is caused by 2. ___________ strains.
- serotype B
- nonencapsulated strains
Haemophilus influenzae nonencapsulated strains clinical presentation:
Haemophilus influenzae nonencapsulated strains & Haemophilus parainfluenzae colonize in first few months of life the 1_______ and therefore causes 2.__________ infections, rather than disseminated infections.
- colonize the upper respiratory tract
- localized infections = otitis media, sinusitis, bronchitis, penumonia
Most common cause of ENCAPSULATED Haemophilius influenzae infection is in:
invasive serotype = B
unvaccinated children
Encapsulated Haemophilus Influenzae clinical presentation in unvaccinated children:
Which type of Haemophilus influenzae is the INVASIVE DISEASE causing bacteria?
Which type of Haemophilus influenzae is the NON-invasive disease causing bacteria?
Name the non-invasive RTI (respiratory tract infections) caused by unencapsulated Haemophilus influenzae
Haemophilus influenzae virulence factors:
- pili and adhesins - mediate coloniation to oropharynx
- LPS - leading to damage of respiratory epithelium & can enter blood if capsulated
- POLYSACCHARIDE CAPSULE - leading to dissemination
- IgA1 protease - facilitate colonization
Haemophilus Influenzae encapsulated form has a polysaccharide capsule with a specific name:
PRP - poly-ribitol phosphate
- risk group - infants aged 6 to 4 years - lack of specific antibodies
- patients with complement deficiency
- patienst undergone splen-ectomy
Encapsulated (type b) Haemophilus influenzae prevention:
Hib vaccination:
- vaccine composed of capsule (PRP) polysaccharide CONJUGATED with protein (mutant diphteria toxin protein)
Which of the Haemophilae is also named Koch-Weeks bacillus ?
Haemophilus aegyp-tius
Haemophilus aegyp-tius has a second name:
Koch-Weeks bacillus
Encapsulated (type b) Haemophilus Influenzae leads to:
Name opportunistic pathogens of Haemophilae:
Haemophilus parainfluenzae can not only cause local infection but also ?
endocarditis
Name Bacteria of Yersinia genus:
Yersinia pestis
Yersinia pseudo-tuberculosis
Yersinia entero-coli-tica
Yersinia pestis clinical presentation:
- plague – bubonic plague – „black death“ - (boubon = greek means groin)
- pneumonic plague
- septicemic plague
Yersinia pestis prevents phagosome-lysosome fusion why ?
It is FACULTATIVE intracellular pathogen
Yersinia pestis transmission:
ZOONOSIS
1. human to human by air-borne route = pneumonic plague
2. Vectors = bitten by infected fleas
3. Direct contact = by touching dead rodents
Yersinia pestis reservoir:
Rats – rodents wild= nagetiere = URBAN plague
Squirrels = SYLVATIC plague
What is sylvatic plague in yersinia pestis?
Is the plague caused in Squirrels
Yersinia pestis virulence factors:
Facultative intracellular organism
1. Fraction 1 (F1) – capsular antigen is antiphagocytic
2. V & W antigen
3. Toxin = pesticin
4. Capsule
Yersinia pestis staining:
bipolar staining – the ends of coccobacillus stain stronger than the center
Yersinis pestis clinical presentation of bubonic plague:
SYSTEMIC SPREAD via bloodstream to liver, lungs etc. = SEPSIS
hemorrhages under skin causes blackish discoloration =black death
75% die if untreated
Bubonic plague caused by Yersinia pestis can lead to?
Septicemic plague – endotoxin responsible
Which Bacteria causes the so called „Black Death“
Yersinia pestis – bubonic plague -transmitted by vectors (fleas)
