Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Flashcards
Neisseria Meningitidis prevention used?
- vaccination against polysaccharide capsule serotypes A,C,Y and W135
- leaving off the serotypes X and B
But a differnet vaccination for type B is now also avialable
Neisseria Gono-rrhoe-ae (gone-seed/ rhoia- flow) transmission:
Neisseria Gono-rrhoe-ae (gone-seed/ rhoia- flow) reservoir:
Neisseria Gono-rrhoe-ae (gone-seed/ rhoia- flow) source?
Neisseria Gono-rrhoe-ae (gone-seed/ rhoia- flow) virulence factor:
- ß-lactamase - degrade penicillin - only some strains
- pili - prevent phagocytosis by neutrophils
- IgA1 protease
- Porin proteins (PorB) - major outer membrane protein - must be active to be pathogenic - porA is silent in N.gonorrhoeae
- LOS - lipooligosaccharide
- able to survive intracellular killing
- OMVs ( outer membrane vesicles)
Which of the two strict pathogens of Neisseria has a polysaccharide capsule?
Neisseria Meningitidis - meningococcus
Neisseria gonorrhoeae in MEN is restricted to the______?
urethra
Neisseria gonorrhoeae in MEN cause acute symptomatic symptom name it:
Neisseria gonorrhoeae in men rarely causes COMPLICATIONS name them:
Neisseria gonorrhoeae in WOMAN primary site of infection is:
Neisseria gonorrhoeae in 10 to 20% of WOMAN can cause ascending genital infections explain:
- salpingitis
- tubo-ovarian abscesses
- PID
Neisseria gonorrhoeae in 1% to 3% of WOMAN gono-cocc-emia can appaer explain:
Gono-cocc-emia:
- is the DISSEMINATED INFECTION
- with septicemia & infection of the skin& joints
- pustular rash on extremities
- purulent arthritis
Neisseria gonorrhoeae can also lead to other syndromes name them:
- perihepatitis (fitz-hugh-curtis syndrome)
- oph-thalmia neo-natorum - purulent conjuncticitis in newborns infected during vaginal delivery
- anorectal gonorrhea in homosexual men
- pharyngitis
Neisseria gonorrhoeae in 10 to 20% of WOMAN can cause ascending genital infections for example PID (pelvic inflammatory disease) what could be the complication resulting of PID:
- ectopic pregnancy
- STERILITY
- perihepatitis
- peritonitis - infection of peritoneal fuid
- abscesses - tubo-ovarian abscesses
Moraxella name the most important pathogen:
Moraxella catarrhalis
For Neisseria Meningitidis is a second vaccine aviable, against the polysaccharide capsule, for which serotype?
Murray doesnt name it, but ridiculously simple does
B
Moraxella catarrhalis is:
Moraxella catarrhalis causes three major diseases name them:
- sinusitis
- otitis media - in children age 3 years
- bronchitis - in elderly with COPD
- bronchopneumonia - in elderly with COPD
Moraxella catarrhalis mostly affects RISK GROUPS name them;
- childern age 3 years
- elderly with COPD (chronic obstructive pulmonary disease)
- immunosuppressed
Moraxella catarrhalis reservoir:
Moraxella catarrhalis in immunosuppressed patients causes?
Bord-e-tella is
Bordetella four species are pathogenic name them:
- Bord-e-tella pertussis -pertussis or whooping cough
- Bord-e-tella parapertussis - milder form of pertussis
- Bord-e-tella bronchi-septica -occasionally humans, usually animals - bronchopulmonary disease
- Bord-e-tella holmesii- uncommon cause of sepsis - septicemia
Bordetella RESERVOIR:
Bordetella transmission:
Bordetella pertussis virulence factors responsible for adhesion or colonalization to ciliated epithelial cells:
- fimbria
- per-tactin
- filamentous hemag-glutinin (FHA)
Bordetella pertussis virulence factors responsible for localized tissue damage are toxins name them:
- Dermo-necrotic toxin
- Tracheal cytotoxin
- Pertussis toxin - systemic toxicity
- Adenylate cyclase
- LPS -endotoxin
Bordetella pertussis primary infection is:
whooping cough - pertussis
Bordetella pertussis primarily affects what risk group:
children (pediatric group)
Bordetella pertussis also affects ?
- adults with waning immunity
- having milder diseases
- missdiagnosed with flu or cold
Bordetella Pertussis classical presentation of pertussis proceeds through 3 STAGES name them:
- Catarrhal Stage
- Paroxysmal Stage
- Con-vale-scent stage
Bordetella pertussis causes whooping cough or pertussis, is it highly contagious?
Yes - but depending on what stage infected patient is
Bordetella pertussis before classical presentation of pertussis perceeds there is a:
Incubation period of 7 to 10 days
Bordetella pertussis proceeds in three stages,name & explain the first stage
Catarrhal Stage:
- most contagious stage
- highest amount of bacterial culture
- last 1-2 weeks
- non-specific symptoms
Bordetella pertussis proceeds in three stages,name & explain the 2ndstage:
Par-oxy-smal Stage:
- less contagious
- lasts 2-4 Weeks
- characterized by classic whooping cough paroxysms
- vomiting often follows attack
- red eyes due to cough
Bordetella pertussis proceeds in three stages,name & explain the 3rdstage:
Con-vale-scent Stage:
- non-contagious
- diminishing paroxysms
- SECONDARY COMPLICATION: Seizure, Ence-phalopathy, Pneumonia, death
IN which stage of pertussis can secondary complications appear and name them:
- 3rd stage - convalescent stage
- secondary complications are = seizure, ence-phalopathy, death, pneumonia
Adults with vaccination against bordetella pertussis can become infected, is that true?
YES it is true :
If the immunity is waning than they show milder diseases (chronic persisten cough) – often misdiagnosed as flu or cold
Bordetella pertussis in which of the 3 stages is the highest amount of bacterial culture?
Bord-e-tella pertussis prevention:
VACCINATION:
- DTP - whole-cell vaccine components
- DTaP - acelullar vaccine components
