Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Lernkarten
Chlamydophila pneumonia reservoir
Chlamydophila pneumonia specific SEROTYPE
Chlamydophila pneumonia most commonly causes:
Chlamydophila pneumonia usually is
Chlamydophila pneumonia clinical presentations are also:
For dectection of chlamydophila pneumonia and psittaci we use:
For dectection of chlamydia trachomatis we use:
Legionella pneumophila reservoir
Legionella pneumophila its morphology
Legionella pneumophila transmission
Legionella pneumophila Virulence Factors
- facultative intracellular organism -inhibit phagosome-lysosome fusion
- produce PROTEOLYTIC ENZYMES- (phosphatase,lipase, nuclease)
- parasitzie in amebae in the water ( parasite amoebas)
- BIOFILMS
- LPS
- host factors - cytokines & chemokines, cellular immune response
Legionella pneumophila causes three specific clinical presentations name them:
- legion-naires disease / legionnellosis - severe pneumonia
- Pontiac fever - influenza-like illness
- asymptomatic - relatively common
Legionella pneumophila causes legionellosis/ legonnaires disease:
- causes severe pneumonia = DESTRUCTIVE PNEUMONIA
- risk group : >40 years and hospitalized (nosocomial infection)
- leading to death in 75% of immunosupp.
- SYSTEMIC SIGNS: multiorgan disease = CNS, GI tract, Liver, Kidneys
Legionella pneumophila causes pontiac fever what is different to legionnaires disease?
- is a influenza-like illness
- is symptomatic
- caused by hypersensitivity reaction to endotoxin
Legionella pneumophila can be DIAGNOSED by:
Name all atypical bacteria:
- Chlamydophila pneumonia
- Chlamydophila psittaci
- Chlamydia trachomatis
- Legionella pneumophila
- Mycoplasma pneumonia - Eatons Agent
- Mycoplasma hominis
- Mycoplasma genitalium
- Ureaplasma Urealyticum
Name the 2 strictly pathogenic neisseria forms:
- neisseria gonor-rhoeae
- neisseria meningitidis
Neisseria morphology:
Neisseria is:
Saprophytic strains of Neisseria RESERVOIR
- NATURAL FLORA: mucosal surfaces of the oropharynx, nasopharynx, genitourinary
Neisseria transmission
Neisseria meningitidis major virulence factor:
Neisseria meningitidis has a polysaccharide capsule name the relevant serotypes
Neisseria Meningitidis is also known as
Meningo-coccus
Neisseria Meningitidis (meningococcus) VIRULENCE FACTORS:
- pili - provide resistance to killing by neutrophils
- IgA1 protease
- able to survive intracellular killing
- LOS - lipooligosaccharide - lacks O-antigen
- OMVs (outer membrane vesicles)
- polysaccharide capsule - A,B,C,W135,X,Y
- outer membrane proteins - por proteins, Opa proteins, Rmp proteins
Neisseria requires what for growth:
Neisseria virulence factor the LOS - lipooligosaccharide stimulates what?
- stimulates the release of the pro-inflammatory cytokine tumor necrosis factor-alpha
- which causes most of the gonococcal diseases
Which virulence factors of Neisseria cause attachment and penetration into host cells?
- pilli
- opa protein
- porB protein
Neisseria Meningitidis usually affects risk groups name them:
Risk groups affected due to lack of specific antibodies against polysaccharide capsule
Neisseria Meningitidis serotype 1. ________ predominately causes in countries 2.________ & 3. _______ the diseases 4._______& 5._______
- 1. B,C,Y
- 2. europa
- 3. america
- 4. meningitis
- 5. meningo-coccemia
W135 - in chile - meningitis
A - to 80-85% in Africa - meningitis
Neisseria Meningitidis serotype Y & W135 are most commonly associated with:
Meningococcus transmission:
- inhalation of respiratory droplets
- close-contact (army recruits/military barracks)
- due to asymptomatic host - STRICT PATHOGEN
Neisseria Meningitis or meningococcus clinical presentation:
Neisseria Meningitis can cause MENIGITIS in INFANTS if treated what sort of neurologic sequelae ?
If untreated = 100% mortality
Neisseria Meningitis can cause Septicemia also known as
meningo-cocc-emia
Neisseria Meningitis can cause Septicemia / Meningo-cocc-emia explain
- life-threatening disease
- PETECHIAL RASH - due to release of endotoxin, causing vascular necrosis & hemorrhage into surrrounding skin
- Waterhouse-Friderichsen syndrome - acture hemorrhagic adrenalitis - bilateral destruction of adrenal gland
- Purpura fulminans
Neisseria Meningitidis causes in SEPTICEMIA the symptom Waterhouse-Friderichsen syndrome explain
- acute hemorrhagic adrenalitis
- it is adrenal gland failure due to bleeding
- either bilateral destruction of adrenal gland or unilateral(less common)
Neisseria Meningitidis causes in SEPTICEMIA the symptom fulminans purpura explain
- acute, often fatal, thrombotic disorder
- leading to skin necrosis with DIC ( disseminated intravascular coagulation)
- bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin
Neisseria Meningitidis can cause also other milder syndromes name them:
- urethritis
- arthtirits
- pneumonia - meningococcal pneumonia
Neisseria Meningitidis name predisposing factors:
- lack of specific antibodies ( infants aged 6month to 2 years) when passive transfer of maternal antibodies wane after 6 month of age
- complement deficiency (C5,C6,C7 or C8)
