Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Lernkarten
Chlamydias Developmental Cycle begins with ELEMENTARY BODIES name characteristics:
- EB are metabolically inactive, non-replicating INFECTIOUS forms
- Rigid Outer membrane - resistant to harsh enviromental cond. OUTSIDE HOST
- EB bind on receptors of columnar epithelial cells
- EB INHIBIT PHAGOSOME-LYSOSOME fusion - then 2nd form follows
Chlamydias Developmental Cycle continuous with RETICULATE BODIES name characteristics:
- RB/IB = metabolically active, REPLICATING , non-infectious forms
- via ENDOCYTOSIS EB enters cell
- EB than in PHAGOSOME
- after 6-8h EB starts reorganization into RB
- RB ungergos binary fisson in INCLUSION BODY
- after 18-24h RB condense into EB
- after 48-72h EB released for furhter infection
- for DNA/RNA/PROTEIN synthesis needs ATP - steeling it from host - thus ENERGY PARASITE & Intracelullar organism
Chlamydias Developmental Cycle is completed when ?
Name the 3 species of Chlamydia
- Chlamydia tracho-matis
- Chlamydophila psittaci
- Chlamydophila pneumonia
Chlamydia trachomatis primarily infect the?
Chlamydophila psittaci and Chlamydophila pneumonia primarily infect the ?
Chlamydia trachomatis causes
Chlamydia Trachomatis causes TRACHOMA explain its symptoms
- Trachoma - a chronic conjunctivitis (chronic inflammatory granulomas)
- disease of poverty (asia& africa)
- causes inflammation and scarring
- secondary bacterial infection
- finally leading to preventable BLINDNESS (develops slowly over 10-15years)
- Chlamydia serotypes - A,B,Ba,C - responsible for TRACHOMA
Chlamydia Trachomatis causes Worldwide Diseases of Eye and Genitals name them
Chlamydia Trachomatis causes Worldwide Respiratory System Disease:
Which two bacteria cause non-gonococcal-urethritis (NGU) ?
Which bacteria causes gonococcal urethritis ?
Chlamydia trachomatis has a peptiodoglycan layer ?
Chlamydia Trachomatis causes Worldwide a disease caused by Serovar LGV 1-3 name it:
Chlamydia Trachomatis causes asymptomatic CERVICITIS leading to PID (pelvic inflammatory disease) explain the problem:
- asymptomatic Cervicitis causes SPREADING of infection from cervix to UTERUS, FALLOPIAN TUBE & OVARIES
- spreading of infection named -PID (pelvic inflammatory disease)
- PID in fallopian tube leads to SCARRING -> causes INFERTILITY & tubal (ectopic) pregnancy
Chlamydiaceae have LPS in cell wall ?
Serovar explain:
serovar = are based on antigenic differences in the MOMP of Chlamydiaceae
specific serovars are associated with specific diseases
MOMP - major outer membrane protein
3 MOMP in C. trachomatis:
- A,B,Ba,C
- D-K - most common
- LGV 1-3
Which serovars are the most invasive choose:
Chlamydia trachomatis transmission
Transmission:
- eye-to-eye by droplets,hands, contaminated clothing, flies(vector), fecal contamination - TRACHOMA
- autoinoculation - adult inclusion conjunctivitis
- oral-genital contact - adult inclusion conjunctivitis
- sexual intercourse - NGU
- during birth - infant pneumonia/conjunctivitis
Chlamydia trachomatis transmission in adult inclusion conjunctivits
Transmission:
- Auto-inoculation
- Oral-genital contact
Chlamydia trachomatis transmission in neonatal conjunctivitis / pneumonia
Transmission:
- during birth (mother-to-child)
Chlamydia trachomatis transmission in GENITOURINARY TRACT infections
Transmission :
- sexual intercourse
- serovar D-K
Chlamydia Trachomatis serovars D-K cause in infants what ?
INFANT PNEUMONIA
- leading to rhinitis ( irritation and inflammation of mucos membrane in nose)
- pharyngitis
- distinctive STACCATO Cough
Chlamydia trachomatis serovars LVG 1-3 causes second stage of infection in woman:
Chlamydia Trachomatis serovars LGV 1-3 cause lymphogranuloma venereum explain:
lymphogranuloma venereum:
- chronic sexually transmitted disease
- painless ulcers - heal spontaneous
- second stage of infection - ingunial buboes & lymphedema
- bacteria migrate to lymph nodes - leading to SYSTEMIC SPREAD
Chlamydia Trachomatis complication of UROGENITAL infections are:
Chlamydia Trachomatis SEQUEALE in WOMAN:
Chlamydia Trachomatis SEQUEALE in MEN:
Reservoir of Chlaymdia Trachomatis
- mainly children - in TRACHOMA
- asymptomtic patients - in urogenital infection
Chlamydophila Psittaci transmission:
- INHALTATION of dried excrement (feces), urine, or respiratory secretion of psittacine birds
- Very RARE- person-to-person
Chlamydophila Psittaci reservoir
Chlamydophila Psittaci RISK GROUP
Chlamydophila Psittaci has a very specific clinical presentation name it:
Which serovars in Chlamydia cause adult inclusion conjunctivitis?
Chlamydiaceae Virulence Factors :
- obligate intracellular orgaism - prevent phagolysome fusion
- energy parasite
- developmental cycle
- LPS but weak endotoxin
Psittacosis caused by C. Psittaci diseases also known as
ornithosis (parrot fever)
In Chlamydophila psittaci after inhalation of bacteria what happens?
- lungs-blood-liver and spleen - enter lungs & are spread to reitculoendothelial cells of liver & spleen to multiply
- multiplication leads to formation of FOCAL NECROSIS
- Focal necrosis causes HEMATOGENOUS SPREAD to lungs
- mucous plugs in bronchioles develop - causing CYANOSIS & ANOXIA (hypoxia)
- CYANOSIS - bluish & purpulish discoloration of tissue due to lack of O2
Chlamydophila psittaci causes hematogenous spread leading to SYSTEMIC symptoms name them:
Chlamydophila psittaci causes most commonly
Chlamydophila pneumonia transmission
