Microbiology TEST 2
Lectures 5 - 7
Lectures 5 - 7
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Flashcards
Yersinia Pestis clinical presentation due to human-to-human spreads by aerosols:
Yersinia enterocoli-tica clinical presentation:
Which Yersinia genus causes ENTEROCOLITIS:
Yersinia enterocoli-tica transmission:
Yersinia enterocoli-tica reservoir:
animals (wild & domestic rodents )
Yersinia entero-colitica causes enterocolitis what might be the complictaion:
- reactive arthritis
- erythema nodosum
Yersinia pseudo-tuberculosis clinical presentation:
reservoir - environment
appendicitis-like syndrome
Which zoonotic bacteria is the most INFECTIOUS bacteria known:
Francisella tularensis
Franci-sella tula-rensis Virulence Factors:
Capsule
LPS
Facultative Intracellular
Franci-sella tula-rensis reservoir:
- rabbits
- fish
- reptiles
- other mammals = >100 animals
- Ticks
Franci-sella tula-rensis transmission:
ZOONOSIS
1. hematogenous spread from skin– ulceroglandular tularemia
2. eye contact - oculoglandular tularemia
3. INGESTION = food-poisoning– ty-phoidal tularemia
4. INHALATION = airborne route– inhalation of aerosolization of bacteria during skinning (häuten) or evi-scera-tion (ausnehmen) of infected rabbit = pneumonic tularemia
5. INSECT-BITE = vectors– bite of tick or deerfly – ulcero-glandular/glandular tularemia
6. INFECTED TISSUE (inoculation)-direct contact with wild rabbit
Francisella Tularensis causes Tularemia which is also known as:
- Rabbit fever
- Tick fever
- Glandular Fever
- Deerfly Fever
Glandular fever/ Rabbit fever/ Tick fever / Deerfly Fever are also known as:
Tularemia caused by Franci-sella Tularensis
Franci-sella Tula-rensis two most important clinical presentations:
ulcero-glandular tularemia & pneumonic tularemia
Franci-sella Tula-rensis Clinical Presentation due to contact with infected tissue:
1. ulcero-glandular tularemia – painfull ulcers with regional lympha-denopathy
2. glandular tularemia – no ulcers but regional lymphadenopathy
Franci-sella Tula-rensis Clinical Presentation due to ingestion of contaminated water or food:
1. ty-phoidal tularemia – gastrointestinal diseases
2. oro-pharyngeal tularemia – painful pharyngitis
Franci-sella Tula-rensis Clinical Presentation due to inhalation of infectious aerosoles:
pneumonic tularemia -aerosolization of bacteria during skinning and evi-scer-ation
Francisella Tularensis Clinical Presentation due to eye contact with contaminated fingers or contaminated material splashed into eye:
oculo-glandular tularemia -ulceration of conjunctiva = conjunctivitis with regional lympha-denopathy
Francisella Tularensis Clinical Presentation due to hand-to-mouth contact:
ORO-pharyngeal tularemia – painful pharyngitis (pseudomembrane may develop over tonsils – often mistaken with diphteria)
Francisella Tularensis Clinical Presentation due to insect bite by tick or deerfly:
Ulcero-glandular tularemia
Which two clinical presentations of Franci-sella Tula-rensis lead to SYSTEMIC INFECTION:
ulcero-glandular tularemia & ty-phoidal tularemia
– entering bloodstream affecting other organs e.g. Lungs = pneumonic tularemia / ACUTE SEPTICEMIA
Which of the clinical presentations of Francisella Tularensis is the MOST SEVERE FORM:
pneumonic tularemia
Name all 6 clinical presentations caused by Francisella Tularensis:
Ulceroglandular tularemia – most common & systemic infection
Glandular tularemia -2ndmost common ( difference no ulcers but lympha-denopathy
Oculo-glandular tularemia
Oro-pharyngeal tularemia
Ty-phoidal tularemia -systemic infection
Pneumonic tularemia – most severe
Which of the clinical presentations of Francisella Tularensis is NOT lymphadenopathy & NOT ulcer causing:
Ty-phoidal tularemia
Which of the Zoonotic Bacteria is the one considered as biological weapon?
Francisella Tularensis as it is highly infectious (extremely virulent) & easy dissemination
(also brucella possibly)
Name all Zoonotic facultative intracellular bacteria:
Yersinia genus
Francisella Tularensis
Brucella genus
Name all Zoonotic extracellular pathogen:
Pas-teu-rella Multo-cida reservoir:
wild & domestic animals
cats and dog natural flora – mouth
Pas-teu-rella Multo-cida transmission:
lick, scratch or bit from dog/cat
Pas-teu-rella Multo-cida virulence factors:
- capsule
- dermo-necrotic toxin
- LPS
- multiply extracellular
Pasteurella multo-cida is
Pas-teu-rella Multo-cida clinical presentation:
Localized abscesses
COMPLICATION : Osteo-myelitis & Septic Arthritis – due to closure of wound, optimal condition for growth
Immunosuppressed & Infants = Disseminated Diseases = Septicemia – due to lick in face
Worsening ( ex-a-cer-bation – verschlimmern) of chronic respiratory disease in patients with pulmonary disorder
Brucella name its subgroups:
Brucella meli-tensis – goats
Brucella canis – dogs
Brucella abortus – causes abortion in cows
Brucella suis – pig
The Clinical Diseases „Brucellosis“ caused by Brucella bacteria can also be named:
Bang disease – named after microbiologist Bernhard Bang
clinical presentation: UNDULANT FEVER
Name the Zoonotic bacteria which is non-encapsulated & facultative intracellular pathogen:
Brucella
Brucella is?
Risk groups of Brucella:
Laboratory personnal – inhalation or direct contact
Conutries with low domestic animal vaccination program – travel-associated disease
(Blood or organ tissue transfer)
Brucella transmission:
Inhalation – can be used for bioterrorism
Ingestion – foodborne = milk products – unpasteurized = major source of infection
Direct contact with animals or animal products
Brucellosis most commonly caused by which genus of Brucella ?
Brucella meli-tensis – due to ingestion of contaminated milk products (unpasteurized)
Brucella Virulence Factors:
LPS
Toxic enzymes
Facultative intracellular parasite in reticuloendothelial cells
