Basics in Physiology for BME (Lecture 3)
415060-HS2022-0 -Master Biomedical Engineering BME Uni Bern
415060-HS2022-0 -Master Biomedical Engineering BME Uni Bern
Somatosensory cortex
Schwann-cell
polymodal nociceptors
unimodal nociceptors
Aδ-fibres(~15 m/sec; 1.0-1.5 μm)
mediate the first pain
C-fibres(~1 m/sec; 0.3-0.5 μm)
mediate the second pain
Nociceptors possess a high activation threshold
peripheral desensibilization
Spinal cord
Pain mediating substances
Head-Zones
to thalamus
Aβ/Aδ-fibres
Peripheral control
Spinal cord
Dorsal horn
more than 6 month
without
nociceptive afferents
more excitable
Meissner corpuscle
Merkel
disk
Pacini corpuscle
Hair follicle
sensor
Merkel
disk
Ruffini
corpuscle
Str. corneum
Epidermis
Corium
Subcutis
Hair follicle
sensor
SA –slowly adapting
RA –rapidly adapting
Meissner corpuscle
Merkel disk
Ruffini corpuscle
Sensor potential (generator potential)
Somatosensation
(pressure)
Resting state
Membrane expansion by pressure
Nervus medianus
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Meissner corpuscle
Merkel
disk
Pacini corpuscle
Hair follicle
sensor
Merkel
disk
Ruffini
corpuscle
Str. corneum
Epidermis
Corium
Subcutis
Hair follicle
sensor
SA –slowly adapting
RA –rapidly adapting
Meissner corpuscle
Merkel disk
Ruffini corpuscle
Sensor potential (generator potential)
Somatosensation
(pressure)
Resting state
Membrane expansion by pressure
Nervus medianus
Meissner corpuscle
Pacini corpuscle
Grey matter
White matter
receptor
Spinal nerve
Size of receptive fields increases from distal to proximal
Lemniscal system
Anterolateral system
Primary somatosensory
cortex (areas1, 2, 3a, 3b)
Slowly
adapting
spinal cord
Brain stem
Somatosensory cortex
Schwann-cell
polymodal nociceptors
unimodal nociceptors
Aδ-fibres(~15 m/sec; 1.0-1.5 μm)
mediate the first pain
C-fibres(~1 m/sec; 0.3-0.5 μm)
mediate the second pain
Nociceptors possess a high activation threshold
