Clinical Pharmacology
Clinical Pharmacology
Clinical Pharmacology
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Cartes-fiches
TPMT is responsible for the metabolism of?
To antimicrobial efficacy - concentration dependent. (pattern of bacterial killing) correlated with AUC/MIC, Peak/MIC belong the following group of antibiotics
Which of the following are enzyme inhibitors?
The first-pass effect:
The persistent inhibition of bacterial growth after antibiotic elimination from the body is called:
The goal of therapeutic drug monitoring of methotrexate is:
At what time the notification of severe adverse drug reaction is made:
The recommended comparator in pharmacoeconomic analysis is:
The most frequently observed adverse events in short time use of biological drugs should not be:
Do indomethacin can be given with paracetamol:
During the use of oral antidiabetic drugs may lead to hyperglycemia, if the patient also uses:
In organ transplant patients statin of choice should be:
The change in the bioavailability of drugs substantially undergoing the first-pass effect in the elderly is the result of:
In order to avoid harmful consequences associated with impaired excretion of the drug substance in a renal disease, the following dosages of drugs:
The indication of therapeutic drug monitoring of aminoglycoside antibiotics should not be:
The combined use of ketoconazole and erythromycin may: (1 point)
171) Which of the following statements is correct?
Antihistamine agents used for allergicrhinitis have antagonistic activity against both H1 and H2 receptors:
Possible risks for patient taking part in clinical trial
Genetically targeted therapy monitored concentration of the drug in the body can be used for medical treatment:
Fast increasing the dose of methadone or administration of a high dose can cause:
Among the NSAIDs in the elderly is desirable to use:
During the treatment of the elderly should be avoided:
A person being ultra-fast metabolism (carrier 5 copies of the gene CYP2D6) were treated with a tricyclic antidepressant. It is necessary to dose:
Among analgesics most commonly causes damage to the bone:
A significant increase in plasma digoxin concentration may result in combined therapy with:
Increased risk of depression in the elderly may be associated with the use of:
Inadvisable and inconsistent with the principles of optimizing the use of analgesics is pairing:
Poor CYP2D6 phenotype of oxidation can cause:
Drug metabolism may be affected
Factors which can increase the fraction of unbound drug
During interpretation of child-pugh score, 8-9 points (liver dysfunction) requires dose reduction of liver-metabolised drugs by
Reduction (decreased surface) of gastrointestinal tract can cause:
Iatrogenic response (effect):
What drugs does alpha-1- acid glycopprotein bind?
This can reduce the efficacy of oral contraceptives and should not be used together:
ketoconazole and itraconazole are potent inhibitors of which P450?
In the mechanistic classification of adverse drug reactions, which of the following statements best describes type A (augmented):
Who must report ADR:
what physiologic change associated with normal aging may affect Mr. Jones, 80 year old, clinical response to amiodarone?
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Which type of pharmacoeconomic analysis uses Quality adjusted life years as an outcome?
