Immunology TEST 1

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This flashcard set covers university-level immunology, focusing on cells, antibodies, antigens, and immune responses. It delves into topics like flow cytometry, lymphocyte activation, and the roles of various immune cells such as NK cells and T cells. The flashcards are designed for medical students and professionals seeking to understand the intricate mechanisms of the immune system, including antigen recognition, immune responses, and diagnostic tests like the NBT reduction assay and flow cytometry. The set provides a comprehensive overview of both specific and non-specific immune responses, making it valuable for those studying medical science or pharmaceutics.

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177

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Sprache

Englisch

Kategorie

Medizin/Pharmazie

Stufe

Universität

Erstellt / Aktualisiert

28.04.2020 / 20.04.2021

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The tritiated thymidine incorporation test is aimed to assess:

Cell proliferation

Cell death receptor activation

Cell necrosis

cell cytotoxicity

Cell proliferation

Cell death receptor activation

Cell necrosis

cell cytotoxicity

The tritiated thymidine incorporation test is one of the basic tests in the assessment

of:

Antigen stimulated cell proliferation

Death receptor-induced cell apoptosis

Toxic agent-induced cell necrosis

Mitogen stimulated cell cytotoxicity

Antigen stimulated cell proliferation

Death receptor-induced cell apoptosis

Toxic agent-induced cell necrosis

Mitogen stimulated cell cytotoxicity

The valency of an antibody is defined as:

The strength of a single antigenic determinant binding to an antibody molecule

The overall strength of a multivalent antigen binding to an antibody

The number of antigenic determinants bound by the antibody

The number of paratopes bound by an antibody

The strength of a single antigenic determinant binding to an antibody molecule

The overall strength of a multivalent antigen binding to an antibody

The number of antigenic determinants bound by the antibody

The number of paratopes bound by an antibody

Thymus-dependent antigens, these are:

Generated only in the thymus

Presented to the T cells only in the thymus

Inducing antibody synthesis due to the Th support

Produced by B cells on the T helper support

Generated only in the thymus

Presented to the T cells only in the thymus

Inducing antibody synthesis due to the Th support

Produced by B cells on the T helper support

To assess T cell proliferation there should be used:

Tritiated thymidine incorporation test

NBT absorption and reduction test

Radial immunodiffusion test

Tryptan blue staining test

Tritiated thymidine incorporation test

NBT absorption and reduction test

Radial immunodiffusion test

Tryptan blue staining test

To assess the presence of anti-eurythrocyte antibodies in blood

serum, the follow- ing test can be used

Direct Coombs test who already bound to the surface of RBC

Indirect Coombs Test

none of above

Direct Coombs test who already bound to the surface of RBC

Indirect Coombs Test

none of above

To detect an enzyme defect in the neutrophil oxidative

metabolism, the following test is used:

50% hemolysis CH50 test

Tryptan blue staining test

Nitroblue tetrazolium (NBT) reduction test

Radioactive chromium 51Cr release test

50% hemolysis CH50 test

Tryptan blue staining test

Nitroblue tetrazolium (NBT) reduction test

Radioactive chromium 51Cr release test

To distinguish general population of NK cells and T cells, the

surface markers should be:

CD4, CD8, CD16

CD3, CD14, CD56

CD3, CD45, CD56

CD4, CD16, CD56

CD4, CD8, CD16

CD3, CD14, CD56

CD3, CD45, CD56

CD4, CD16, CD56

To identify populations of monocytes and T-helper cells in PBMC’s,

most probably there should be assessed:

CD3 CD4 CD45

CD3 CD8 CD25

CD4 CD16 CD56

CD4 CD14 CD45

CD3 CD4 CD45

CD3 CD8 CD25

CD4 CD16 CD56

CD4 CD14 CD45

To identify populations of NK cells and T-cell in the peripheral

blood cell population there should be assessed:

CD3 CD45 CD56

CD4 CD8 CD16

CD3 CD4 CD19

CD3 CD14 CD56

CD3 CD45 CD56

CD4 CD8 CD16

CD3 CD4 CD19

CD3 CD14 CD56

Typical non-specific immune response cells are:

macrophages, NK cells

macrophages, T and B lymphocytes

T lymphocytes

dendritic cells, T cells

macrophages, NK cells

macrophages, T and B lymphocytes

T lymphocytes

dendritic cells, T cells

Which of the following descriptions of the immune response

should not be referred to HYPERRACTIVITY:

excessive

predictable

specific

to a harmful stimulus

excessive

predictable

specific

to a harmful stimulus

Which of the following statements is NOT true:

B cells - recognize and present protein antigens to T helper cells

NK cells - able to cytotoxicity

T cells- able to phagocytosis

Dendritic cells - present antigens to T helper cells

B cells - recognize and present protein antigens to T helper cells

NK cells - able to cytotoxicity

T cells- able to phagocytosis

Dendritic cells - present antigens to T helper cells

Which of the following statements, describing the essential activities of cells involved

in the immune response, is false:

B lymphocytes- recognize and present peptide antigens to helper T lym- phocytes

NK cells- have the cytotoxicity capacity

T lymphocytes- have the cytotoxicity and phagocytosis capacity

Dendritic cells- present antigens to helper T lymphocytes

B lymphocytes- recognize and present peptide antigens to helper T lym- phocytes

NK cells- have the cytotoxicity capacity

T lymphocytes- have the cytotoxicity and phagocytosis capacity

Dendritic cells- present antigens to helper T lymphocytes

Antigenicity, this is

The feature of a paratope that conditions its capacity of being specifically recognized by antibodies

The feature of an antigen that conditions its capacity of specific immune response activation

The feature of an epitope that conditions its capacity of being specifically recognized by a paratope

The feature of an antigen that conditions its capacity of being specifically recognized by an antigen determinant

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

The feature of a paratope that conditions its capacity of being specifically recognized by antibodies

The feature of an antigen that conditions its capacity of specific immune response activation

The feature of an epitope that conditions its capacity of being specifically recognized by a paratope

The feature of an antigen that conditions its capacity of being specifically recognized by an antigen determinant

A blood smear, this is a test aimed basically to assess:

Red blood cell count

Hemoglobin amount

Platelets count

White blood cell pattern

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

Red blood cell count

Hemoglobin amount

Platelets count

White blood cell pattern

The essential elements of the specific recognition in the immune system are

An antigen, an antibody, the complement

An Antibody, a BCR, a TCR

An epitope, a paratope, the complement

A MHC, a HLA, a denditric cell

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

An antigen, an antibody, the complement

An Antibody, a BCR, a TCR

An epitope, a paratope, the complement

A MHC, a HLA, a denditric cell

The acquired immune response can be characterized by the below

features with the EXCEPTION of

High specificity

Immune memory

Invariability

High variability

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

High specificity

Immune memory

Invariability

High variability

A Fab composition in an antibody

(-> allotopes, which are non-varying structures on the Fc receptor.)

determines antibodies class

determines antibody sub class

determines the epitope binding capacity?

determines the antibody allotrope?

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

determines antibodies class

determines antibody sub class

determines the epitope binding capacity?

determines the antibody allotrope?

To identify populations of NK cells and T-cell in the peripheral

blood cell population, there should be assessed

(Midterm Set II)

CD3, CD45, CD56

CD4, CD8, CD16

CD3, CD4, CD19

CD3, CD14, CD56

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

CD3, CD45, CD56

CD4, CD8, CD16

CD3, CD4, CD19

CD3, CD14, CD56

A HIV infection diagnostic procedure referred to as a confirmation

test should be

ELISA (detection of anti-gp 120)

Western blot

ELISA (detection of anti-p24)

Flow cytometry (immunophenotyping of CD4+, CD8+, CD20 + cells)

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

ELISA (detection of anti-gp 120)

Western blot

ELISA (detection of anti-p24)

Flow cytometry (immunophenotyping of CD4+, CD8+, CD20 + cells)

The phagoburst test in the flow cytometry allows

(Midterm Set III)

To determine the number of viable cells that are capable to absorb bacteria

To determine the number of fluorescent-labelled bacteria, phagocytes by a single phagocyte

To assess the formation of reactive oxygen species by Nitroblue tetrazolium reduction to formazans in phagocytes

To assess the formation of reactive oxygen species by substrate oxidation to a fluorescent compound in phagocytes

Tastatur-Befehle:

= drehen,

= vor-/rückwärts,

= scrollen

To determine the number of viable cells that are capable to absorb bacteria

To determine the number of fluorescent-labelled bacteria, phagocytes by a single phagocyte

To assess the formation of reactive oxygen species by Nitroblue tetrazolium reduction to formazans in phagocytes

To assess the formation of reactive oxygen species by substrate oxidation to a fluorescent compound in phagocytes

After a density gradient PBMC isolation, the cell viability must be

assessed. The proper dye is

(Midterm Set III)

Nitroblue tetrazolium (NBT)

Blue formazans

Trypan blue

CFSE

Nitroblue tetrazolium (NBT)

Blue formazans

Trypan blue

CFSE

A Peyer's patch, this is:

encapsulated organ of gastrointestinal tract lymphatic tissue

non-encapsulated structure of gastrointestinal tract lymphatic tissue

Waldeyer's ring component

A microfolded cell (M-cell)

encapsulated organ of gastrointestinal tract lymphatic tissue

non-encapsulated structure of gastrointestinal tract lymphatic tissue

Waldeyer's ring component

A microfolded cell (M-cell)

Select the set of surface antigens that best characterize NKT cells

(Midterm Set III)

CD3-, CD16+, CD45+, CD56+

CD3-, CD14+, CD16+, CD45+

CD3+, CD16+, CD45+, CD56+

CD3+, CD19+, CD45+, CD56+

CD3-, CD16+, CD45+, CD56+

CD3-, CD14+, CD16+, CD45+

CD3+, CD16+, CD45+, CD56+

CD3+, CD19+, CD45+, CD56+

A test applied to detect the oxygen metabolism enzyme defect

should be:

50% hemolysis- CH50

Trypan blue uptake

Nitroblue tetrazolium reduction test (NBT)

Radioactive chromium release assay

50% hemolysis- CH50

Trypan blue uptake

Nitroblue tetrazolium reduction test (NBT)

Radioactive chromium release assay

The set of antigens that comprise different cell molecules,

associated with its differentiation, maturation and function is

termed as

(Midterm Set III)

Immunophenotype

Genotype

Idiotype

Allotype

Immunophenotype

Genotype

Idiotype

Allotype

A test that is NOT aimed for cell isolation is:

MACS (magnetic-associated cell sorting)

FITC (fluorescein induced T cell isolation)

FACS (fluorescence-associated cell sorting)

Density gradient cell centrifugation

MACS (magnetic-associated cell sorting)

FITC (fluorescein induced T cell isolation)

FACS (fluorescence-associated cell sorting)

Density gradient cell centrifugation

The innate immune components do not include

(Midterm Set IV)

NK cells

TCD4+ lymphocytes

mast cells

macrophages

NK cells

TCD4+ lymphocytes

mast cells

macrophages

Abnormal proportions of individual protein fractions observed in

the electrophoretic separation of serum proteins is termed:

paraproteinemia

dysproteinemia

hypoproteinemia

macroglobulinemia

paraproteinemia

dysproteinemia

hypoproteinemia

macroglobulinemia

The antigen determinant, this is

(Midterm Set IV)

The paratope

An epitope

A portion of an antibodies that binds the epitope on the antigen

A portion of an antigen that binds the Fc portion of an antibody

The paratope

An epitope

A portion of an antibodies that binds the epitope on the antigen

A portion of an antigen that binds the Fc portion of an antibody

The antigen-antibody complex activates the complement in the

pathway

(Midterm Set IV)

lectin

alternative

classic

mannose

lectin

alternative

classic

mannose

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Cartes-fiches

Typical non-specific immune response cells are:

macrophages, NK cells

macrophages, T and B lymphocytes

T lymphocytes

dendritic cells, T cells

Which of the following chemical compounds does not arise after

activation of NADPH oxidase in the pathogen elimination process

The O2

H2O2

OH-

Which of the following descriptions of the immune response

should not be referred to HYPERRACTIVITY:

excessive

predictable

specific

to a harmful stimulus

Which of the following statements is NOT true:

B cells - recognize and present protein antigens to T helper cells

NK cells - able to cytotoxicity

T cells- able to phagocytosis

Dendritic cells - present antigens to T helper cells

Which of the following statements, describing the essential activities of cells involved

in the immune response, is false:

B lymphocytes- recognize and present peptide antigens to helper T lym- phocytes

NK cells- have the cytotoxicity capacity

T lymphocytes- have the cytotoxicity and phagocytosis capacity

Dendritic cells- present antigens to helper T lymphocytes

Which of the properties characterizes the specific immune response against the

thymus dependent antigens:

Synthesis of antibodies requires the cooperation of T cytotoxic cells

Synthesis of antibodies requires the cooperation of PRR

The antigen are produced in the thymus

The antibodies are mainly in the IgG1 and IgG3 class

The antibodies are mainly in the IgM class

Which of the statements describing the essential activities of cells participating

in an immune response is WRONG:

Dendritic cells - present antigens to auxiliary lymphocytes

NK cells - capable of specifically identifying cells infected with the virus

Eosinophile - capable of controlling parasites

B-lymphocytes recognize protein antigens presenting auxiliary lymphocytes

Tc lymphocytes capable of cytotoxicity and production of perfumers and granzymes

Which of the substances present in NK cells cytoplasmic granules,

is responsible for the cytotoxic activity of the cells

properdin

Lysozyme

IL-1

Perforin

Which type of hypersensitivity best describes neonatal hemolytic

disease caused by incompatibility in the Rh range:

anaphylactic

Cytotoxic

Immune complexes

Delayed

Atopic

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