IS
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Cartes-fiches
immunity is the capability of the body to
resist pathogens and infectious disease
infectious agents (4)
viruses, bacteria, fungi, parasites
Infection is the _
invasion of pathogens into an organism resulting in illnes
bacteria on the_and in the_are part of our _
skin and in the gut of our natural microbiota
prevention of infection
anatomic and chemical barriers: epithelia of skin, gut, lungs normal microbiota
early: 4-96 h
innate immune cells: macriphages, granulocytes, natrual killer cells
late >96h
adaptive immunity
b/t-cells
Innate Immunity (2 components)
macrophages and granulozyten
fever (body temperature_)
chemicals from immune cells (_) induce the_ to _ general _
38 degree
cytokines, the brain, rise, body temperature
adaptive immunity (2 arts)
bone marrow cells (C-cells)
thymus cells (t-cells)
Immunological memory
response 1. and 2.
initial exposure --> primary immune response (small)
secondary exposure. --> secondary immune response (high) amount of AB
Immunoglobulins
(2)
AB and AG
AB: _ produces by the _ to recognize _and_
AB= protein produced by the body to recognize pathogens and activate immune cells
AG = _ or_recognized by the _
protein or peptide recognized by the AB
AG (4 ex)
pathogen fragments (host immunity)
tumor cells (anti-cancer)
harmless environmental proteins (allergy)
self-proteins (autoimmunity)
immunity is the bodies capacity to_ itself from_
protect, infection
the IS is composed of_ (_) in the _,_ and_
white blood cells (leukocytes) in the blood , lymphoid organs and tissues
Innate immune cells react _ to combat infection
fast
Adaptive IS develops _ AB and defense mecahnisms after_
pathogen-specific, primary infection
immunological _is maintained by_ cells of_ immunity
memory, memory, adaptive
immunological disorders occur when the IS is either _ (_) or _(_)
weakened (infection) or overreacting (autoimmunity, allergy, chornic inflammation)
too little leads to_
(5) disease
infection
primary immunodeciencies
HIV/AIDS
lekemia
immunosuprressive drugs
bone marrow irradiation
too much leads to
3 disease
damage of host tissue
chronic inflammation
auto-immunity= immunological response against self
allergy and hypersensitivity= reaction against harmless AG
autoimmunity (DEF)
immune response against host tissue
Systemic Lupus erythematodes (SLE)
(DEF)
Prev (%, gender and geographically)
inflammation of skin, vessels and connective tissues: can potentially affect every organ
prev: 0.04%, woman>men, non caucasians >causcasians (europide)
Lupus typical
butterly rash
Lupus unspecific symtoms
clinical symtpoms, inflammation parameters
