GIT 2
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Morbus Crohn
Location
patchy transmural inflammation
may affect any part of GI tract
UC
Location, affects, where does it start
diffuse mucosal inflammation limited to colon
affects rectum, may involve all or part of rest of colon
UC (arts)
proktitis, linksseiten kolitis, ausgedehnte kolotis
Morbus Crohn epidemiology
Localisation (where), gender, incidence
western countries, no gender, increasing incidence
Symptoms at time of diagnosis M.Crohn
Diarrhea > 6 weeks 90%, Abdominal pain 60-80%, Weight loss (anorexia) 60%
• Blood in the stool 40-50%• Malaise, fever 23-30%• Extraintestinal manifestations 45%
Imaging MC
10% inflammation of _
most common in _
small intestine
most common in terminal ileum
Imaging MC
15% with_
fistula, abscesses
Imaging MC
MRI and Ct enterography and US
Therapy MC Medication
Anti TNF
Gladdbladder Stone RF
Female, Fat, Fecund, Fair, Fourty +, increasing with aging, modern industrialized world
Epi Elevated liver function test
strong increase correlation with RF for_
NAFLD
Elevated Liver Level
RF (5)
life style (sex, tattoo)
medication (NSAR)
Personal history (Blood transfusion prior 1990)
Co Morbidities (M4)
Holidays
NAFLD (5)
Obesity, DMT2, hyperlipidemy, hyertension, M4
Transient Elastography
measure_ using_
elasticity using sound waves
stifness determined by multiple factors (Transient elastography)
2x
degree of fibrosis
degree of inflammation- not good for acute hepatitis
degree of steatosis
not effective in _
morbildy obese patients
HCV medication
DAAs (nowadays it can be treated)
the prevalence decreased
Symtoms of elevated liver level
Icterus, spider neeavi, ascites
esophageal varices risk
bleeding
