Genetik 2_Genomes and Genomics
Genetik 2_Genomes and Genomics
Genetik 2_Genomes and Genomics
-
- 1 / 31
-
Lernkarten
computational information systems and analytical methods applied to biological problems such as genomic analysis.
chromatin immunoprecipitation. The use of antibodies to isolate specific regions of chromatin and to identify the regions of DNA to which regulatory proteins are bound.
Analysis of the relation of the genome sequences of 2 or more species.
The nucleotide sequence of a segment of DNA that is in agreement with most sequence reads of the same segment from different individuals.
Variation for a large DNA segment among homologous chromosomes caused by differences in the numbers of tandem copies of a single or multiple genes.
A group of single-stranded DNA molecules that can be amplified into many copies.
A cDNA clone for which only the 5' or 3' ends or both have been sequenced. Used to identify transcript ends in genomic analysis.
The study of the patterns of transcript and protein expression and of molecular interactions at a genome-wide level.
A large-scale, often multilaboratory effort required to sequence a complex genome.
A library encompassing an entire genome.
The cloning and molecular characterization of entire genomes.
A member of a pair of homologous chromosomes.
A set of DNAs containing all or most genes in a genome deposited on a small glass chip.
A gene-sized section of a sequenced piece of DNA that begins with a start and ends with a stop codon. It is presumed to be the coding sequence of a gene.
Genes in different species that evolved from a common ancestral gene by speciation.
Taxa outside of a group of organisms among which evolutionary relationships are being determined.
In whole-genome shotgun sequence assembly, the DNA sequences corresponding to both ends of a genomic DNA insert in a recombinant clone.
Genes that are related by gene duplication in a genome.
To favor the simplest explanation involving the smallest number of evolutionary changes.
The evolutionary history of a group.
Determining the state of a character or the direction of a change in a character based on the distribution of that character within a phylogeny of organisms.
A pseudogene that arose by the reverse transcription of a mature mRNA and ist integration into the genome.
A mutationally inactive gene for which no functional counterpart exists in wild-type populations.
DNA sequencing technology that is based on the generation and detection of a pyrophosphate group liberated from a nucleotide triphosphate.
An experimental procedure that begins with a cloned segment of DNA or a protein sequence and uses in through directed mutagenesis to introduced programmed mutations back into the genome to investigate the function.
A method used to determine the transcribed regions of a genome within some specific cell population, tissue, sample, or organism.
1. The central framework of a chromosome to which the DNA solenoid is attached as loops. Composed largely of topoisomerase. 2. In genome projects, an ordered set of contigs in which there may be unsequenced gaps connected by paired-end sequence reads.
The compilation of thousands or millions of independent DNA sequence reads into a set of contigs and scaffolds.
A group of overlapping cloned segments.
A situation in which genes are arranged in similar blocks in different species.
two-hybrid test
A method for detecting protein-protein interactions, typically performed in yeast.
