TBPP_albumin

single polypeptide chain (585 AS), molecular weight: 66 kDa (relative small), highy negatively charged at pH 7.4 (-19), pI 4.8, non-glycosylated, 8 double and 1 single loup: hydrophobic inside hydrophilic outside, 70% Alpha-Helix no Beta-sheets, 35 cysteins, 17 disulfide bridges, 1 free thiol, disulphides: 9 loop-link-loop structures. 3 similar domains, each of them 2 subdomains (IA,IB. IIA,IIB. IIIA,IIIB)

synthesis in the liver (10-15g/day), most abundant protein in plasma (35-50g/L, 50%), second most abundant protein in the body (4-5g/kg) ca. 350g total, 40% intravascular and 60% extravascular, half life: 20 days

kidneys (10%), large organs/muscle/skin (80%), gastro intestinal tract (10%), broken down into AS

diffusion of fluid through semi-permeable membrane from a solution with a low solute concentration (hypotonic) to a solution with a higher solute concentration (hypertonic) until equal concentration on both sides. Osmotic: degree of osomotic force produced by fluid. Oncotic: osmotic force caused by protein in plasma.

water, albumin, electrolytes. Intra- and extravascular space, extra- and intracellular space, interstitial space. Fluid balance: normal distribution of water and its solutes within different compartments, essential to health.

separates intra- and extravascular space, 7-9 micrometre in diameter, one cell thick, as semi-permeable membrane

COP is the major fluid shifting force pulling fluid into intravascular space, COP attracts fluid into the blood vessel at venule end of capillary, COP exerted by colloids (albumin), also oncotic pressure. 90% resorption, 10% goes to the lymph by hydrostatic pressure.

high pressure at arterial end of capillaries pushes liquid and nutrients into interstitial space (then to tissues). Albumin contributes 80% of the COP in blood, negative charge: retention of diffusable ions, albumin retains 18ml of water per gramm, 20L of fluid to interstitial space per day