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Kartei Details
| Karten | 47 |
|---|---|
| Sprache | English |
| Kategorie | Chemie |
| Stufe | Universität |
| Erstellt / Aktualisiert | 25.01.2016 / 01.05.2016 |
| Weblink |
https://card2brain.ch/box/drugs_in_forensic_toxicology
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| Einbinden |
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Outline the Marquis test (4p)
1. Test for alkaloids
2. Contains 2% formaldehyde
3. Purple in the presence of heroin, morphine, and most opium derivaties
4. Orange-brown with amphetamines and methamphetamines
Outline the Duquenois-Levine (DL) test. (3p)
1. Test for cannabinoids
2. Solution A - 2% vanillin + 1% acetaldehyde in ethyl alcohol
Solution B - concentrated HCl
Solution C - Chloroform
3. Positive = purple colour in chloroform layer
Outline the Van Urk test (3p)
1. Test for LSD
2. 1% solution of p-dimethylaminobenzaldehyde in 10% concentrated HCl and ethyl alcohol
3. Positive = turns blue-purple
Outline the Scott test (4p)
1. Test for cocaine
2. Solution A - 2% cobalt thocyanate dissolved in water and glycerin (1:1); positive = blue
3. Solution B - concentrated HCl; positive = clear pink
4. Solution C - chloroform; positive = blue reappears
What are microcrystalline tests based on, and what are 2 pros and 2 cons? (5p)
1. Microcrystalline tests are based on the formation of a precipitate in reaction of drug with the added reagent
2. Thought to be more selective than traditional colour tests because of the presence of the precipitate, as well as the characteristics of the crystals used in evaluation of results
3. Rapid-acting
4. Effects of the overally drug matrix may still affect interpretation
5. Require confirmation by another method with superior sensitivity and selectivity
What must confirmatory tests result in? (1p)
At least 2, completely different descriptors
How is a sample prepared for confirmatory analysis, and what are two methods? (3p)
1. Sample preparation consists of dissolution and selective extraction of the drugs
2. Chromatography for retention time/factor
3. Mass spectroscopy for collecting the abundance of chemical, retention time, etc.
