Basics in Physiology for BME (Lecture 2)

415060-HS2022-0 -Master Biomedical Engineering BME Uni Bern

415060-HS2022-0 -Master Biomedical Engineering BME Uni Bern


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Karten 70
Sprache English
Kategorie Medizin
Stufe Universität
Erstellt / Aktualisiert 30.09.2022 / 28.10.2022
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exocytosis
•Fusion of vesicles with the cell membrane
•Triggered by Ca2+ influx through voltage dependent Ca2+
channels when an action potential invades the active zone

endocytosis
•Budding of vesicles
•Vesicles can locally be recycled and loaded with neurotransmitter again or they are cleared via the endosome system

Synaptic vesicle

Synaptic cleft

Neurotransmitters

Ligand-gated channel

G-protein coupledreceptors

Neurotransmitter

Excitatory postsynaptic potential (EPSP)

endplate potentials

Muscarinic
receptor

Nicotinic
receptor

Agonist

Antagonist

Glutamate

NMDA receptor

AMPA and Kainate receptors
Become permeable to Na+and K+
when glutamate is bound

NMDA receptor

postsynaptic density (PSD)

Postsynatpic dendrite

Dendritic spine

NMDA receptor

hyperpolarization

Inhibitory postsynaptic potentials (IPSP).

GABAA-receptor

G protein

Spatialsummation

Temporal summation

“Shunting inhibition”

sodium channels