Cartes mémoires Pharma quizzes (Seite 11 von 12)

Cartes-fiches	463
Langue	English
Catégorie	Médecine
Niveau	Université
Crée / Actualisé	23.06.2022 / 01.08.2022
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7. Which of the pharmacological action is the pharmacological action of beta-blocking drugs

1. dilation of peripheral arteries

2. decrease in heart rate

3. decrease in myocardial contractility

4. decrease in blood pressure

A) only 1

B) only 1, 4

C) only 2, 3

D) only 1, 2, 3

E) only 2, 3, 4

8. Which of the drugs listed below possess combined alpha- and beta-blocking activity

1. carvedilol

2. celiprolol

3. labetalol

4. carteolol

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 3

E) all answers are correct

9. Selective alpha-1 adrenoreceptor antagonists could be used in the treatment of

1. benign prostatic hyperplasia

2. erectile dysfunction

3. chronic hypertension

4. glaucoma

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 3

E) all answers are correct

10. Increase in systolic and diastolic blood pressure is produced by

A) norepinephrine

B) epinephrine

C) isoproterenol

D) drugs A and B

E) drugs A, B and C

11. Urinary bladder wall is relaxed after activation of

A) alpha-1 receptors

B) beta-1 receptors

C) beta-2 receptors

D) alpha-2 receptors

E) M3 receptors

12. Which statement about antagonism and antagonists is true

A) the degree of inhibition produced by a competetive antagonist is independent of the concentration of antagonist

B) primary action of antagonists is to prevent agonists from activating receptors

C) the duration of action of irreversible antagonist depends on its own rate of elimination

D) answers A) and B)

E) answers A), B) and C)

13. Which of the following statements well characterize oral absorption

1. variable absorption

2. usefulness in unconscious patients

3. slower onset of action than in parenteral administration

4. high risk of severe and acute adverse reactions

A) only 1, 3

B) only 3, 4

C) only 4

D) all except 2

E) all statements mentioned above

14. If the volume of distribution of drug is e.g. 2L it can be assumed that the drug

A) is distributed only in plasma

B) is distributed in plasma and tissues

C) is stored in a depot in a tissue e.g. in bones

D) is distributed only inside the cells

E) it is impossible to predict where the drug is distributed

15. The purpose of phase III of clinical trials is to

A) establish safety

B) establish efficacy and detect adverse effects

C) verify efficacy and detect adverse effects

D) obtain additional data following approval

E) obtain data about drug interactions

16. For the drug with T0,5 = 5 hours time needed to eliminate from the body 97% of drug is

A) 5 hours

B) 10 hours

C) 20 hours

D) 25 hours

E) 50 hours

19. Which of the drugs is not used in gout

1. ASA

2. probenecid

3. colchicine

4. anakinra

A) only 1

B) only 1, 4

C) only 2, 3

D) only 1, 2, 3

E )only 2, 3 and 4

20. Characteristic adverse effect of selective COX-2 inhibitors withdrawn from market was

1. cranial hemorrhage

2. increased risk of thrombosis

3. peptic ulcers

4. weight gain

A) only 1, 3, 4

B) only 4

C) only 2

D) only 2, 3

E) only 2, 4

21. Which of the following metabolites of Vitamin D is synthesized in skin?

A) calciferol

B) 25-hydroxycalciferol

C) cholecalciferol

D) 1-25 dihydroxycalciferol

E) none of listed above

22. Vitamin K promotes synthesis of proteins that are involved in the coagulation of blood including all listed below except

A) factor II

B) factor VII

C) factor V

D) factor X

E) C and S protein

23. Which of the following statements is not true for pellagra

A) may cause general malaise

B) is caused by vitamin B6 deficiency

C) typical symptoms include sore and swollen tongue

D) all are true

E) all are false

24. Changes of tongue surface are typical for all listed below except

A) vitamin B1 deficiency

B) vitamin B2 deficiency

C) niacin deficiency

D) biotin deficiency

E) folic acid deficiency

25. Which of the following drugs is correctly matched to its side effects visible in oral cavity

A) ciclosporin A - gum hypertrophy

B) glucocorticoids-candidiasis

C) azathioprine - petechiae

D) lefunomide - glossitis

E) all above are correctly matched

27. Which of following drugs is used in chronic gout

A) colchicine

B) paracetamol

C) indometacine

D) all listed above

E) none of listed above

1. Selective beta-1 agonist is

A) dopamine

B) dobutamine

C) dopexamine

D) drugs A & B

E) drugs A, B, C

2. Which of the drugs may be used in bronchial asthma or COPD

1. metacholine

2. sameterol

3. pirenzepine

4. pratopium

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 3

E) all answers (1-4) are correct

3. Indication for beta-blockers (beta adrenoreceptor antagonists) are

1. stable angina

2. glaucoma

3. heart failure

4. anxiety states

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 3

E) all answers are correct

4. Which may be adverse effects of NSAIDs

1. skin rashes

2. acute renal insuffiency

3. peptic ulcer

4. liver disorder

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 3

E) all answers are correct

5. Which statement about pethidine is true

A) belongs to the partial (mixed) opoid agonists

B) is used in chronic pain

C) may cause anticholinergic effect

D) is given in transdermal patches

E) all statements are false

6. Which statement about paracetamol is NOT true

A) it probably inhibits COX-3

B) it has got toxic intermediate metabolite

C) it is given orally

D) it may be administered to children

E) intravenous acetylcysteine potentiate its toxicity

7. Which opioid belongs to the mixed agonists

A) colchicine

B) probenecid

C) sulfinpyrazone

D) allopurinol

E) rasburicase

9. Which adverese effect of old (sedative) antihistamines in incorrectly paired with its mechanism:

A) weight gain - blockade of serotonin receptors

B) tachycardia - blockade of muscarinic receptors

C) sleepiness - blockade of histamine receptors

D) urinary retention - blockade of alpha receptors

E) QTc prolongation - blockade of potassium current

10. Which drug is used as antiemetic

A) ondansetron

B) bromocriptine

C) ergotamine

D) sumatriptan

E) none of the above

11. To the direct-acting cholinomimetics belong

1. neostigmine

2. pilocarpine

3. atropine

4. betanechol

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 4

E) all answers are correct

12. Overdose of paracetamol is mainly connected with

A) nephrotoxicity

B) aplastic anemia

C) liver failure

D) seizures

E) gastrointestinal bleeding

14. Disadvantages of powder as dosage forms are

1. problems with making the unpleasent taste

2. bulk powders are not suitable for strong acting drugs

3. great variation of dose in bulk powders

4. drugs may be inactivated in e.g. stomach

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 4

E) all answers are correct

15. Which statements are true Malignant hyperthermia

1. may be inducted by halothane

2. is caused by heat prodution in liver

3. is treated with dantolen

4. susceptibility to malignant hyperthermia is connected with mutations in the gene encoding the ryanodine receptor

A) true are II and III

B) true are I and IV

C) true are II, III, IV

D) true is only IV

E) all statements are true

16. Which pair "anesthetic - side effect" is incorrect

A) halotan - hepatitis

B) enfluran - convulsions

C) isofluran - exacerevration of cardiac ischaemia

D) desfluran - bronchospasm

E) nitrous oxide - hypotonia

17. Which statement is incorrect while considering ketamine?

A) depress respiration

B) decrease cardiac contractility

C) rises intracranial pressure

D) has good analgesic effect

E) produces good amnesia

18. Which one of the drugs beneath belongs to the partial agonists of opioid receptors

A) morphine

B) naloxon

C) nalorphine

D) diamorphine

E) codeine

20. Tolerance extentds to most pharmalogical effects of morphine. Which action does it affect much less than the others

A) analgesia

B) emesis

C) constipation

D) euphoria

E) respiratory depression

21. To NSAIDs selective for COX-2 belongs

A) aspirin

B) celecoxib

C) ibuprofen

D) meloxicam

E) paracetamol

22. Which of the side effects of NSAIDs listed beneath is characteristic only for selective COX-2 inhibitors

A) increased risk of thrombosis

B) peptic ulcer

C) gastrointestinal bleeding

D) impaired renal function

E) aspirin asthma

23. Which of the drugs listed beneath belong to DMARDs

1. leflunomide

2. allopurinol

3. methotrexate

4. colchicine

A) true are I, III

B) true are II, IV

C) true are I, III, IV

D) true is only IV

E) all drugs belong to DMARDs

24. The study of genetic influences on responses to drug is called

A) pharmacogenomics

B) pharmacoepidemiology

C) biopharmacology

D) pharmacogenetics

E) pharmacokinetics

25. Factors which may affect gastrointestinal absoprtion of drugs are

1. gastrointestinal motility

2. splanchnic blood flow

3. gastrointestinal pH

4. particle size and formulation

A) only 4

B) only 1, 3

C) only 2, 4

D) only 1, 2, 4

E) all answers are correct

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