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Flashcards	463
Language	English
Category	Medical
Level	University
Created / Updated	23.06.2022 / 01.08.2022
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The risk of interaction with cyclosporine is the most possible in the case of:

A - caspofungin

B - micafungin

C - anidulafungin

a)only A and C

b)only B and C

c)only A and B

d)A, B, and C

Which drug is specifically in motion sickness?

a)dicyclomine

b)oxybutynin

c)pralidoxime

d)scopolamine

The highest selectivity to beta-2 adrenergic receptors has:

a)dobutamine

b)prazosin

c)bisoprolol

d)salmeterol

Which antimuscarinic agent is selective to M3 receptors?

a)ipratropium

b)tropicamide

c)atropine

d)dicyclomine

The beta antagonist which dilates blood vessels by additional alpha-1 receptor blockade is:

A - nebivolol

B - carvedilol

C - labetalol

a)only B and C

b)A, B, and C

c)only A and B

d)only A and C

Which drug is an antimuscarinic agent used in COPD?

A - ipratropium

B - tiotropium

C - umeclidinium

a)only A and C

b)only B and C

c)only A and B

d)A, B, and C

Which immunosuppressant drug may cause hypertension as the adverse effect?

a)dimethyl fumarate

b)hydroxychloroquine

c)azathioprine

d)ciclosporine

The mechanism of action the closest to the mechanism of amphotericin B exerts:

a)griseofulvin

b)econazole

c)naftifine

d)natamycin

A chimeric monoclonal antibody targeting EGRF is:

a)bevacizumab

b)pertuzumab

c)ibritumomab

d)cetuximab

What is NOT true about urapidil?

a)blocks alpha-1 receptors in blood vessels

b)blocks beta-1 receptors in heart

c)is used in hypertensive states

d)is injected or infused intravenously

Which drug is selective beta-1 adrenergic agonist?

a)dobutamine

b)clonidine

c)propranolol

d)nebivolol

What is NOT true about ganciclovir?

a)may be used as intraocular implants

b)crosses the blood-brain barrier

c)may case dose-limiting myelosuppression

d)may cause esophagitis and colitis

What is NOT true about acyclovir?

a)topical cream is effective in recurrent genital herpes

b)during IV infusion seizures may occur

c)requires phosphorylation for activation

d)is cleared mainly renally

Stimulation of alpha-1 receptors causes:

a)urinary incontinence

b)constriction of mucosal blood vessels

c)constriction of skeletal blood vessels

d)inhibition of norepinephrine release from nerve endings

Which plasma electrolyte change is the most probable after the administration of epinephrine?

a)increased magnesium

b)decreased potassium

c)decreased chloride

d)increased calcium

Which statement the least characterizes cytisine?

a)antagonizes the action of concomitantly used nicotine

b)is safe in patients with cardiovascular disease

c)is a plant alkaloid

d)resembles in action nicotine

Deficiency of reduced nicotine adenine dinucleotide (NADH) diaphorase system is responsible for the increased risk of:

a)hemolysis

b)methemoglobinemia

c)hepatitis

d)agranulocytosis

Dose-dependent hemolytic anemia (in about 10-20% of patients), esp. within the first week of the therapy, is the most probable during the treatment with:

a)ribavirin

b)ritonavir

c)acyclovir

d)lamivudine

Which are the enzymes responsible for norepinephrine metabolism?

A - MAO

B - COMT

C - NET

a)A, B, and C

b)only A and C

c)only B and C

d)only A and B

Palivizumab is a monoclonal antibody against:

a)HBV

b)HIV

c)RSV

d)CMV

Maraviroc:

a)prevents upper respiratory tract infections in HIV patients

b)binds selectively to the host protein CCR5

c)is the only drug that may be used in monotherapy of HIV

d)is safe in renal impairment due to non-renal excretion

Which is an example of type I immunologic reaction (IgE-mediated)?

a)drug-induced lupus-like syndrome

b)morbilliform rash from sulfonamides

c)hemolytic anemia from penicillin

d)anaphylaxis after penicillins

Which anti HCV drugs are correctly matched with the mechanism of action:

A - "...previr" - NS3/4A protease inhibitors

B - "...asvir" - NS5A inhibitors

C - "...buvir" - NS5B protease inhibitors

a)A, B, and C

b)only A and C

c)only B and C

d)only A and B

The highest risk of pancreatitis is during the treatment with:

a)didanosine

b)efavirenz

c)zidovudine

d)delaviridine

The least useful in the treatment of CMV infections is:

a)abacavir

b)foscarnet

c)cidofovir

d)gancyclovir

In comparison to young adults, geriatric patients have:

a)lower kidney filtration of drugs

b)lower risk of drug-drug interactions

c)higher liver metabolism of drugs

d)higher total body water

Homovanilic acid is the metabolite of:

a)serotonin

b)epinephrine

c)dopamine

d)norepinephrine

Which localization of dopamine receptors is INCORRECT?

a)D1 - brain and renal vasculature

b)D3 - only brain

c)D4 - only cardiovascular system

d)D2 - brain and smooth musclesD3

Which subtype of cholinergic receptors is located in heart?

a)M1 receptors

b)M3 receptors

c)Nm receptors

d)M2 receptors

Which anti-HIV drug may be used during pregnancy?

A - abacavir

B - raltegravir

C - efavirenz

a)only B and C

b)only A and B

c)only A and C

d)A, B, and C

What is NOT true about pegylation of interferon?

a)increases the rate of absorption after SC administration

b)is the attachment of polyethylene glycol to the interferon

c)reduces renal clearance of interferon

d)decreases the immunogenicity of the protein

Which statement about HIV protease inhibitors is NOT true:

a)may inhibit CYP3A4 activity

b)may cause hypoglycemia episodes

c)may cause fat redistribution and lipodystrophy

d)may cause QT interval prolongation

Which tissues are "rich" in beta-1 adrenergic receptors?

A - kidneys

B - heart

C - bronchi

a)only A and C

b)only A and B

c)only B and C

d)A, B, and C

Which is NOT the example of idiosyncratic reaction?

a)NSAIDs-induced gastrotoxicity

b)troglitazone-induced hepatitis

c)chloramphenicol-induced aplastic anemia

d)clozapine-induced agranulocytosis

Which drugs do NOT require phosphorylation for activation?

A - foscarnet

B - abacavir

C - efavirenz

a)A, B, and C

b)only A and C

c)only A and B

d)only B and C

All listed drugs may be used in the treatment of chronic HBV infection EXCEPT:

a)lamivudine

b)interferon alfa-2b

c)tenofovir

d)ledipasvir

Which antiretroviral drug is incorrectly matched with the group:

a)raltegravir - INSTI

b)indinavir – Pl

c)enfuvirtide - NRTI

d)nevirapine-MARTI

Increased secretion in skin eccrine sweat glands depends on the stimulation of:

a)beta-1 receptors

b)beta-3 receptors

c)M receptors

d)alpha-1 receptors

During pregnancy:

a)protein binding of drugs at the maternal side is lower than on the fetal side

b)glomerular filtration in the first trimester is impaired

c)all drugs permeate through the placental barrier

d)maternal nutrients deficiency does not influence the fetal development

Which drug is used in the treatment of giardiasis?

A - metronidazole

B - tinidazole

C - nitazoxanide

a)A, B, and C

b)only A and B

c)only B and C

d)only A and C

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