Test 2 Old Questions Pharma

Direct binding to ergosterol and increased membrane permeability is the MOA of:

The main toxicity of amphotericin B is:

Fluconazole

Amphotericin B is a very useful agent for treating fungal infections. Correct statements regarding amphotericin include:

1. it is both hydrophilic and lipophilic
2. it binds to sterols in the fungal cell membrane
3. a test dose should be administered before treatment begins
4. nephrotoxicity may occur

Dose-limiting nephrotoxicity is characteristic for

To the antimalarial drugs belong all listed below EXCEPT:

Choose INCORRECT indication for metronidazole administration

The antifungal spectrum of echinocandins covers

FOTO3. Men who use large doses of anabolic steroids are at increased risk of which of the following?

Anti-inflammatory and anti-fungal activity is feature of ?

Griseofulvin should be taken with fatty meals (statement 1) because it irritates GI tract when it taken in empty stomach (statement 2)

The main mechanism of action of amphotericin B is

Which drug will be the best for onychomycosis of the toe

Cyclosporine A is under investigation for 

Cinchonism is an adverse effect of

(Poisoning by cinchona, quinine, or quinidine; characterized by tinnitus, headache, deafness, andoccasionally, anaphylactoid shock.))

Metronidazole has action against

A young boy returned from the camp with diarrhea. Giordia lamblio infection was diagnosed. Which of the drug will be suitable for the treatment

Which drug is NOT useful in the treatment of malaria

In beef or pork tapeworm drug of choice is

Which anticancer drug is NOT cell cycle-specific agent:

FOTO34. If the patient is treated with aldendronate, he/she is advised to drink large quantities of water with the tablets and remain in an upright poition for at leas 30min. These instructions are given to decrease the risk of the following? 

Although many anticancer drugs can induce nausea and vomiting, some have a stronger tendency than others. which of the following drugs has the greatest tendency to induce vomiting:

The risk of pulmonary fibrosis is the most characteristic for

choose the monoclonal antibody used in the treatment of chronic lymphocytic leukemia

1. pegademase
2. everolimuse
3. etanercept 
4. ofatumumab

Which of the following drugs may cause liver failure

Which of the following drugs used to treat parasite infections

In the treatment of toxoplasmosis useful is the combination of

Anthelminthic, benzimidazole derivative drugs are

1. Albendazole
2. Thiabendazole
3. Clotrimazole
4. mebendazole 

Which statement about trimethoprim is true:

1. Is fully absorbed from gastrointestinal tract
2. Could be combined with sulfamethoxazole
3. May cause megaloblastic anemia
4. Reaches high concentrations in the lungs

(Sentence 1) Erythropoiesis-stimulating agents (ESAs) may enhance some malignant tumors progression therefore (sentence 2) the dose and duration of ESAs should be minimized in treating anemia caused by cancer chemotherapy.

The main indications for flutamide is

Choose chimeric human-murine monoclonal antibody used in therapy of rheumatoid arthritis and Crohns disease.

Which of the following most accurately describes the immunosuppressant action of sirolimus?

During the second course of chemotherapy this patient developed dysprica???, a nonproductive cough and intermittent fever. Chest x-ray film revealed pulmonary infiltration. Which of the following is the most likely to be responsible for these symptoms?

Which drug binds to a CCR5 receptor of CD4 cells blocking the entry of HIV?

FOTO33. which of the following is the least likely to be responsible for developing of drug-induced osteoporosis:

Which of the following is an immunosuppressant that inhibits pyrimidine synthesis?

Which one of the following drugs may cause severe cardiotoxicity?

It is true that

The drug of choice in the treatment of amebiasisis: