Excipients Biopharmaceuticals

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.


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Cartes-fiches 50
Langue English
Catégorie Médecine/Pharmacie
Niveau Université
Crée / Actualisé 26.06.2018 / 01.07.2018
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trometamolum = TRIS* (2)

alkalizing agent*, buffering agent

sodium hydroxide* (1)

alkalizing agent

Saccharose = Sucrose* (3)

cryopreservants*, bulking agent*, tonicity agent ( hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

hydrochloric acid (1)

acidifying agent

Glutathione* (1)

Antioxidant*

Magnesium sulfate (1)

Buffer salt*

Histidine* (2)

Antioxidant*, buffer*

Calcium chloride (2)

Buffer salt*, Antimicrobial preservative

Methionine* (3)

Stabilizer (viscosity enhancing)*, antioxidant, buffering agent

Magnesium chloride (1)

Buffer salt*

ZnH, Protamin* (1)

Special exipient used for depot insulin*

Alanine* (1)

Antioxidant*

Disodium hydrogen phosphate dihydrate = Sodium Phosphate , Dibasic/monobasic = Disodium Phosphate* (1)

Buffer salt*

Poloxamer 188* (4)

Co-solvent*, surfactant*, dispersing agent; solubilizing agent

Sodium dihydrogen phosphate dihydrate (1)

Buffer salt*

Mannitol* (4)

cryopreservants*, bulking agent*, diluent, tonicity agent (for hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

Trehalose* (3)

Stabilizing agent, cryopreservants*, bulking agent*

NaCl (3)

Isotonizing agent, cryoprotectant*, bulking agent*

Cresols (m-creasol = metacresolum*, paracresolum = p-cresol, ortocresolum = o-cresol) (2)

Antimicrobial preservative; disinfectant

sodium borate = Borax decahydrate = boric acid disodium salt (5)

Alkalizing agent, antimicrobial preservative, buffering agent, disinfectant, stabilizing agent

glacial acetic acid (1)

acidifying agent

N2-Gas* (1)

Antioxidant*

Natrii Chloridi solution (physiological NaCl)* (2)

Solvent*, Isotonizing agent

WFI, Aqua q.s.* (1)

Solvent*

phosphoric acid (H3PO4)* (2)

Acidifying agent, buffering agent

Aluminium hydroxide phosphate sulfate* (2)

Adsorbent, vaccine adjuvant*

Sodium carboxymethyl cellulose (1)

Stabilizer

Potassium chloride (2)

Buffer salt*, tonicity agent

Sodium gluconate (1)

Buffer salt*

Polysorbatum 20/80 = Polyoxyethylene Sorbitan Fatty Acid Esters (2)

Surfactant*, solubilizing agent

Polymers (dextran, polyethylene glycol) (1)

Viscosity enhancers

benzyl alcohol = Benzenemethanol (3)

Antimicrobial preservative, disinfectant, solvent

Albumin (1)

Stabilizing agent

Ammonium sulfate (1)

Buffer salt

sodium citrate = Citric acid trisodium salt (2)

Alkalizing agent, buffering agent

citric acid = Citric Acid Monohydrate = Acidum citricum monohydricum (4)

Acidifying agent, antioxidant, buffering agent, preservative

Glycerin = Glycerol (4)

Antimicrobial preservative, Co-solvent, solvent, tonicity agent

Sodium sulfate (1)

Buffer salt*

Zinc as Zinc oxide, Acetic acid, zinc salt; dicarbomethoxy zinc (1)

stabilizing agent

polylactic acid, DL-lactic polymer, acid copolymer (1)

controlled-release agent