Microbiology TEST 1
Microbiology 4th Semester
Microbiology 4th Semester
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Lernkarten
Gastroenteritis is caused by clostridium perfringes type C can cause a severe symptom name it
Necrotizing enteritis is the severe endogenic infection of clostridium perfringes to what can it lead?
- SEPSIS
- 50% mortality
Clostridium perfringes has 3 toxins name them:
- 12x EXOTOXIN - alpha toxin- lecithinase - lyses RBC, Leukocytes and platelets
- Enterotoxin - in food-poisoning - causes fluid loss
- Degradative Enzyme - Collagenase, Proteases, Hyaluronidase, DNAase - promote spread of infection, liquefy tissue
Necrotising enteritis is caused by clostridium perfringens type
Soft tissue infections, Food-poisoning and Primary septicemia is caused by clostiridum perfringes type
Food-poisoning in clostridium perfringes causes
Necrotizing enteritis is caused by clostridium perfringes type C by the exotoxin
Soft tissue infections in clostridium perfringes name the three
Which of the soft tissue infections in clostridum perfringes is the gas gangrene forming one?
Name major symptoms of myonecrosis
Name symptoms of Cellulitis in clostridium perfringens
Clostridium difficile is
Clostridium difficile has 2 toxins
- enterotoxin - toxin A -diarrhea
- cytotoxin - toxin B - cytotoxic to colonic cells
Clostridium difficle is part of natural flora of
Clostridium Difficile infection develop due to
Clostridium difficiles causes
Which clostridia are part of natural flora /endogenous ?
What does it mean pathogenicity?
- ability of microorganism to cause disease
- degree of pathogenicity is determined by virulence factors
Name routes of transmission of microorganisms to humans
- air-born
- person-to-person
- vector
- food-born
- exposure to contaminated fomites (krankheitsüberträger)
Corynebacterium Diphtheria is endogenous or exogenous
- endogenous - Skin, GI, gentitourinary tract, upper respiratory tract
Corynebacterium Diphtheriae is endogenous name the areas
Corynebacterium Diphtheriae name its morphological structure:
Corynebacterium Diphtheriae grows in aerobic or anaerobic conditions ?
- both, is facultative anaerobic
Corynebacterium Diphtheriae is
Corynebacterium diphtheriae name what happens to diphtheria toxin
What is a lysogenic bacteria ?
- bacteria is infected with temporate bacteriophage
- bacteriophage's DNA is integrated into bacteria's chromosome
- forming new form of virulent bacteria
Corynebacterium Diphtheria is only toxic when?
- when diphtheria toxin was lysed by ß-bacteriophage
- forming the A-B exotoxin of diphtheria toxin
- thus forming the lysogenic C. diphtheriae
RESERVOIR of Corynebacterium Diphtheriae
TRANSMISSION of Corynebacterium Diphtheriae
Which Corynebacterium species produce endogenous infections?
endogenous infection is meant opportunistic infections
Which Corynebacterium species are strict pathogens?
Name virulence factors responsible for all symptoms of diphtheria and explain pathomechanism of the disease.
- the tox gene of diphtheria toxin must be lysed by ß-phage
- by process of proteolytic cleavage
- froming A-B exotoxin
- A-B exotoxin has three regions
- A-subunit - catalytic region
- B-subunit -translocation region & receptor-binding region
- receptor for lysogenic diphteria toxin is the heparin-binding epidermal growth
- which is on many eukaryotic cell surfaces like HEART & NERVE CELLS
- therefore causing typical cardiac and neurological symptoms in diphtheria - a systemic spread
Corynebacterium Diphtheria causes in nonimmune patients:
Respiratory Diphtheria causes
Diphtheria toxin is produces at 1. ___________ and then 2.__________through the blood to produce the 3._________signs of diphtheria.
- 1. site of infection
- 2. disseminated
- 3. systemic
Respiratory Diphtheria developed due to what type of transmission?
air-borne route :
inhaling saliva droplets containing bacteria
Cutaneous Diphtheria developed due to what type of transmission?
person-to-person:
direct contact with skin lesion of an infected host
Cutaneous Diphtheroia causes what type of symptoms
Diphtheria should be considered in
Explain term toxoid - anatoxine
- bacterial toxin whose toxicity has been supressed or weakend
- can be used for safe active immunization
