ECOTOX TOXICODYNAMICS

VL6 & VL7

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Kartei Details

Karten	12
Sprache	Deutsch
Kategorie	Chemie
Stufe	Universität
Erstellt / Aktualisiert	19.05.2023 / 31.05.2023
Lizenzierung	Keine Angabe
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Flip-Modus

Explain the interplay between primary & secondary effects

cells = central site of chemical-organism interaction

if the chemical manages to enter the cell (despite phase 0 cellular defense) a primary interaction can take place -> leads to primary effects (enzyme inhibition, covalent binding) -> if not repaired: secondary effects (skin lesions, reduced growth)

primary interaction can also lead to phase I & II biotransformation which then either leads to 1) detoxification & export, or 2) bioactivation & a more toxic transformation product

What does a primary interaction in a cell consist of (3)

1. target molecule (3 main types)

2. interaction type at target site (3 main types)

3. type of effect

Name the 3 basic types of target molecules and their type of interaction

1. membranes (lipids) -> cell membranes, organelles -> non-specific

2. peptides & proteins -> enzymes (catalytic function), transporters (ABC, ion channels), regulation (transcription factors), structural proteins -> specific

3. DNA -> reactive (formation of covalent bonds, biotransformation)

What is baseline toxicity (3)

- lowest intrinsic "minimal" toxicity: change of membrane fluidity/disturbance of channels -> all substances display baseline toxicity, as they have to enter through the membrane

- reversible

- also called narcosis