MMM, Biomaterials II
MMM (3), Biomaterials II
MMM (3), Biomaterials II
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Kartei Details
| Karten | 12 |
|---|---|
| Sprache | English |
| Kategorie | Technik |
| Stufe | Universität |
| Erstellt / Aktualisiert | 09.01.2019 / 09.01.2019 |
| Lizenzierung | Keine Angabe |
| Weblink |
https://card2brain.ch/box/20190109_mmm_biomaterials_ii
|
| Einbinden |
<iframe src="https://card2brain.ch/box/20190109_mmm_biomaterials_ii/embed" width="780" height="150" scrolling="no" frameborder="0"></iframe>
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advantages of drug delivery
- maintain therapeutic level of drug
- protection of drug and patient (less side effects)
- easy administration
- matching drug release profile to patients needs
- reach hard-to-reach areas (brain)
- implants do not have to be removed
Mab
Monoclonal antibody
Nib
inhibitor
polymer requirements for drug delivery
- safe for clinical use
- degrade into non-toxic products
- tunable degradation rates
- biocompatible
biomaterial challenges
- vascular devices clot blood
- metal implants corrode and leach ions
- implanted sensors encapsulate and fibrose
- contact lenses infect
- implanted valves calcify
- soft tissue implants fibrose, infect
encapsulation of implanted materials
infection after the implantation of a material leads to attraction of neutrophils, they make contact to the surface and induce an immune reaction. macrophages arrive and also fibroblasts. several macrophages then couple up in "Foreign Body Giant Cells FBGCs", they have multiple nuclei. The biomaterial gets encapsulated by fibers built from the fibroblasts.
anti-inflammatory materials
- anionic
- hydrophilic
- softer
- topologies around 1-2 microns
biocompatibility testing procedures
- extract test
- extraxt test: colony formation
- direct contact test
- indirect contact test: agar diffusion test
- indirect contact test: filter diffusion test
