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Excipients Biopharmaceuticals

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

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This flashcard set delves into the role of excipients in biopharmaceuticals, covering university-level concepts. It explores various agents like buffers, salts, and preservatives, including sodium, chloride, and zinc compounds, which are crucial for formulation stability and efficacy. The set also discusses solvents, antioxidants, and tonicity agents, highlighting their importance in drug development. Ideal for students and professionals in pharmaceutics, this flashcard set provides a comprehensive overview of how these excipients contribute to the safety and effectiveness of biopharmaceutical products.
Cartes-fiches
50
Utilisateurs
5
Langue
Anglais
Catégorie
Médecine/Pharmacie
Niveau
Université
Créé / Mis à jour
26.06.2018 / 01.07.2018
  • 1  / 50

Cartes-fiches

Methionine* (3)

Stabilizer (viscosity enhancing)*, antioxidant, buffering agent

Magnesium chloride (1)

Buffer salt*
ZnH, Protamin* (1)

Special exipient used for depot insulin*

Alanine* (1)

Antioxidant*

Disodium hydrogen phosphate dihydrate = Sodium Phosphate , Dibasic/monobasic = Disodium Phosphate* (1)

Buffer salt*

Poloxamer 188* (4)

Co-solvent*, surfactant*, dispersing agent; solubilizing agent
Sodium dihydrogen phosphate dihydrate (1)

Buffer salt*

Mannitol* (4)

cryopreservants*, bulking agent*, diluent, tonicity agent (for hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

Trehalose* (3)

Stabilizing agent, cryopreservants*, bulking agent*

NaCl (3)

Isotonizing agent, cryoprotectant*, bulking agent*
Cresols (m-creasol = metacresolum*, paracresolum = p-cresol, ortocresolum = o-cresol) (2)

Antimicrobial preservative; disinfectant

sodium borate = Borax decahydrate = boric acid disodium salt (5)

Alkalizing agent, antimicrobial preservative, buffering agent, disinfectant, stabilizing agent

glacial acetic acid (1)

acidifying agent

N2-Gas* (1)

Antioxidant*

Natrii Chloridi solution (physiological NaCl)* (2)

Solvent*, Isotonizing agent

WFI, Aqua q.s.* (1)

Solvent*

phosphoric acid (H3PO4)* (2)

Acidifying agent, buffering agent

Aluminium hydroxide phosphate sulfate* (2)

Adsorbent, vaccine adjuvant*
Sodium carboxymethyl cellulose (1)

Stabilizer

Potassium chloride (2)

Buffer salt*, tonicity agent

Sodium gluconate (1)

Buffer salt*

Polysorbatum 20/80 = Polyoxyethylene Sorbitan Fatty Acid Esters (2)

Surfactant*, solubilizing agent
Polymers (dextran, polyethylene glycol) (1)

Viscosity enhancers

benzyl alcohol = Benzenemethanol (3)

Antimicrobial preservative, disinfectant, solvent

Albumin (1)

Stabilizing agent

Ammonium sulfate (1)

Buffer salt

sodium citrate = Citric acid trisodium salt (2)

Alkalizing agent, buffering agent

citric acid = Citric Acid Monohydrate = Acidum citricum monohydricum (4)

Acidifying agent, antioxidant, buffering agent, preservative

Glycerin = Glycerol (4)

Antimicrobial preservative, Co-solvent, solvent, tonicity agent

Sodium sulfate (1)

Buffer salt*

Zinc as Zinc oxide, Acetic acid, zinc salt; dicarbomethoxy zinc (1)

stabilizing agent

polylactic acid, DL-lactic polymer, acid copolymer (1)

controlled-release agent

(hydrolyzed) gelatine, Byco; Cryogel (2)

suspending agent, viscosity-increasing agent

Monosodium L-glutamate (1)

buffering agent

Brij 98 = Polyoxyl 20 oleyl ether = Polyoxyethylene Alkyl Ethers (2)

penetration enhancer, solubilizing agent

Sodium lauryl sulfate = Dodecyl alcohol hydrogen sulfate = sodium salt =dodecyl sodium sulfatesulfate (2)

(Anionic) surfactant, detergent

alcohol anhydrous (4)

Antimicrobial preservative, disinfectant, skin penetrant, solvent

HFA 134a (1,1,1,2-tetrafluorethane) (1)

Propellant

Benzalkonium chloride = Alkylbenzyldimethylammonium chloride (4)

Antimicrobial preservative, antiseptic, disinfectant, solubilizing agent

Glycine (3)

Buffering agent, bulking agent, freeze-drying agent

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