Excipients Biopharmaceuticals

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

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This flashcard set delves into the role of excipients in biopharmaceuticals, covering university-level concepts. It explores various agents like buffers, salts, and preservatives, including sodium, chloride, and zinc compounds, which are crucial for formulation stability and efficacy. The set also discusses solvents, antioxidants, and tonicity agents, highlighting their importance in drug development. Ideal for students and professionals in pharmaceutics, this flashcard set provides a comprehensive overview of how these excipients contribute to the safety and effectiveness of biopharmaceutical products.

Cartes-fiches

Utilisateurs

Langue

Anglais

Catégorie

Médecine/Pharmacie

Niveau

Université

Créé / Mis à jour

26.06.2018 / 01.07.2018

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Acidifying agent, antioxidant, buffering agent, preservative

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Antimicrobial preservative, Co-solvent, solvent, tonicity agent

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Buffer salt*

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stabilizing agent

polylactic acid, DL-lactic polymer, acid copolymer (1)

controlled-release agent

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suspending agent, viscosity-increasing agent

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buffering agent

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penetration enhancer, solubilizing agent

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(Anionic) surfactant, detergent

alcohol anhydrous (4)

Antimicrobial preservative, disinfectant, skin penetrant, solvent

HFA 134a (1,1,1,2-tetrafluorethane) (1)

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Benzalkonium chloride = Alkylbenzyldimethylammonium chloride (4)

Antimicrobial preservative, antiseptic, disinfectant, solubilizing agent

Glycine (3)

Buffering agent, bulking agent, freeze-drying agent

Zinc chloride (1)

Buffer salt*

Phenol = Carbolic acid = hydroxybenzene = oxybenzene (1)

Antimicrobial preservative

trometamolum = TRIS* (2)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

alkalizing agent*, buffering agent

sodium hydroxide* (1)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

alkalizing agent

Saccharose = Sucrose* (3)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

cryopreservants*, bulking agent*, tonicity agent ( hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

hydrochloric acid (1)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

acidifying agent

Glutathione* (1)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Antioxidant*

Magnesium sulfate (1)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Buffer salt*

Histidine* (2)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Antioxidant*, buffer*

Calcium chloride (2)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Buffer salt*, Antimicrobial preservative

Methionine* (3)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Stabilizer (viscosity enhancing)*, antioxidant, buffering agent

Magnesium chloride (1)

Commandes clavier:

= tourner,

= avant/arrière,

= faire défiler

Buffer salt*

ZnH, Protamin* (1)

Special exipient used for depot insulin*

Alanine* (1)

Antioxidant*

Disodium hydrogen phosphate dihydrate = Sodium Phosphate , Dibasic/monobasic = Disodium Phosphate* (1)

Buffer salt*

Poloxamer 188* (4)

Co-solvent*, surfactant*, dispersing agent; solubilizing agent

Sodium dihydrogen phosphate dihydrate (1)

Buffer salt*

Mannitol* (4)

cryopreservants*, bulking agent*, diluent, tonicity agent (for hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

Trehalose* (3)

Stabilizing agent, cryopreservants*, bulking agent*

NaCl (3)

Isotonizing agent, cryoprotectant*, bulking agent*

Cresols (m-creasol = metacresolum*, paracresolum = p-cresol, ortocresolum = o-cresol) (2)

Antimicrobial preservative; disinfectant

sodium borate = Borax decahydrate = boric acid disodium salt (5)

Alkalizing agent, antimicrobial preservative, buffering agent, disinfectant, stabilizing agent

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Cartes-fiches

Zinc chloride (1)

Buffer salt*

Phenol = Carbolic acid = hydroxybenzene = oxybenzene (1)

Antimicrobial preservative

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Excipients Biopharmaceuticals

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