Excipients Biopharmaceuticals

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

Functions of exipients used for Biopharmaceuticals (mainly parenterals, some are used in cases of pulmonary administration systems). Questions: The ones with the Start (*) were discussed in the lecture, the others are listed in the ingredients list of the exercises. The numbers in the brackets idicates the number of functions listed in the answer, which relate to the excipient asked about. Answers: The answers were either discussed in lecture (*) or can be found in the handbook of excipents.

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About these flashcards

This flashcard set delves into the role of excipients in biopharmaceuticals, covering university-level concepts. It explores various agents like buffers, salts, and preservatives, including sodium, chloride, and zinc compounds, which are crucial for formulation stability and efficacy. The set also discusses solvents, antioxidants, and tonicity agents, highlighting their importance in drug development. Ideal for students and professionals in pharmaceutics, this flashcard set provides a comprehensive overview of how these excipients contribute to the safety and effectiveness of biopharmaceutical products.

Flashcards

50

Students

5

Language

English

Category

Medical science/Pharmaceutics

Level

University

Created / Updated

26.06.2018 / 01.07.2018

Polymers (dextran, polyethylene glycol) (1)

Viscosity enhancers

benzyl alcohol = Benzenemethanol (3)

Antimicrobial preservative, disinfectant, solvent

Albumin (1)

Stabilizing agent

Ammonium sulfate (1)

Buffer salt

sodium citrate = Citric acid trisodium salt (2)

Alkalizing agent, buffering agent

citric acid = Citric Acid Monohydrate = Acidum citricum monohydricum (4)

Acidifying agent, antioxidant, buffering agent, preservative

Glycerin = Glycerol (4)

Antimicrobial preservative, Co-solvent, solvent, tonicity agent

Sodium sulfate (1)

Buffer salt*

Zinc as Zinc oxide, Acetic acid, zinc salt; dicarbomethoxy zinc (1)

stabilizing agent

polylactic acid, DL-lactic polymer, acid copolymer (1)

controlled-release agent

(hydrolyzed) gelatine, Byco; Cryogel (2)

suspending agent, viscosity-increasing agent

Monosodium L-glutamate (1)

buffering agent

Brij 98 = Polyoxyl 20 oleyl ether = Polyoxyethylene Alkyl Ethers (2)

penetration enhancer, solubilizing agent

Sodium lauryl sulfate = Dodecyl alcohol hydrogen sulfate = sodium salt =dodecyl sodium sulfatesulfate (2)

(Anionic) surfactant, detergent

alcohol anhydrous (4)

Antimicrobial preservative, disinfectant, skin penetrant, solvent

HFA 134a (1,1,1,2-tetrafluorethane) (1)

Propellant

Benzalkonium chloride = Alkylbenzyldimethylammonium chloride (4)

Antimicrobial preservative, antiseptic, disinfectant, solubilizing agent

Glycine (3)

Buffering agent, bulking agent, freeze-drying agent

Zinc chloride (1)

Buffer salt*

Phenol = Carbolic acid = hydroxybenzene = oxybenzene (1)

Antimicrobial preservative

trometamolum = TRIS* (2)

Keyboard commands:

= turn,

= for-/backward,

= scroll

alkalizing agent*, buffering agent

sodium hydroxide* (1)

Keyboard commands:

= turn,

= for-/backward,

= scroll

alkalizing agent

Saccharose = Sucrose* (3)

Keyboard commands:

= turn,

= for-/backward,

= scroll

cryopreservants*, bulking agent*, tonicity agent ( hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

hydrochloric acid (1)

Keyboard commands:

= turn,

= for-/backward,

= scroll

acidifying agent

Glutathione* (1)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Antioxidant*

Magnesium sulfate (1)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Buffer salt*

Histidine* (2)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Antioxidant*, buffer*

Calcium chloride (2)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Buffer salt*, Antimicrobial preservative

Methionine* (3)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Stabilizer (viscosity enhancing)*, antioxidant, buffering agent

Magnesium chloride (1)

Keyboard commands:

= turn,

= for-/backward,

= scroll

Buffer salt*

ZnH, Protamin* (1)

Special exipient used for depot insulin*

Alanine* (1)

Antioxidant*

Disodium hydrogen phosphate dihydrate = Sodium Phosphate , Dibasic/monobasic = Disodium Phosphate* (1)

Buffer salt*

Poloxamer 188* (4)

Co-solvent*, surfactant*, dispersing agent; solubilizing agent

Sodium dihydrogen phosphate dihydrate (1)

Buffer salt*

Mannitol* (4)

cryopreservants*, bulking agent*, diluent, tonicity agent (for hypertonic/hyperosmotic formulation e.g. in s.c. applications (flux to lymphe node)*

Trehalose* (3)

Stabilizing agent, cryopreservants*, bulking agent*

NaCl (3)

Isotonizing agent, cryoprotectant*, bulking agent*

Cresols (m-creasol = metacresolum*, paracresolum = p-cresol, ortocresolum = o-cresol) (2)

Antimicrobial preservative; disinfectant

sodium borate = Borax decahydrate = boric acid disodium salt (5)

Alkalizing agent, antimicrobial preservative, buffering agent, disinfectant, stabilizing agent

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Flashcards

Zinc chloride (1)

Buffer salt*

Phenol = Carbolic acid = hydroxybenzene = oxybenzene (1)

Antimicrobial preservative

1
2

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