Microbiology Antomicrobials

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Tetracyclines

General mechanism: resistance is common, bacteriostatic

Spectrum of activity: GP & GN

                       Treat: atypical pneumonia, syphilis, brucellosis, borrelliosis

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Glycylcyclines

General mechanism: active against bacteria resistant to tetracyclines

Spectrum of activity: GP & GN

- GP cocci: staphylococcus, enterococcus, streptococci

- GN GI rods, except proteus

- GN nonfermentative rods

- Obligate anaerobes

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Aminoglycosides

General mechanism: bactericidal except against staphylococcus

Spectrum of activity: GN aerobic bacilli, no activity against anaerobes % GP bacteria, except staphylococcus

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Aminoglycosides

General mechanism: bactericidal except against staphylococcus

Spectrum of activity: GN aerobic bacilli, no activity against anaerobes % GP bacteria, except staphylococcus

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Aminoglycosides

General mechanism: bactericidal except against staphylococcus

Spectrum of activity: GN aerobic bacilli, no activity against anaerobes % GP bacteria, except staphylococcus

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Aminoglycosides

General mechanism: bactericidal except against staphylococcus

Spectrum of activity: GN aerobic bacilli, no activity against anaerobes % GP bacteria, except staphylococcus

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Aminoglycosides

General mechanism: bactericidal except against staphylococcus

Spectrum of activity: GN aerobic bacilli, no activity against anaerobes % GP bacteria, except staphylococcus

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Bacteriostatic

active onky against gonococci

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Macroslides

General mechanism: 

Spectrum of activity: Mainly GP cocci (streptococci, staphylococci, campylobacter, helicobacter, borrelia)

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Macroslides

General mechanism: 

Spectrum of activity: Mainly GP cocci (streptococci, staphylococci, campylobacter, helicobacter, borrelia)

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Macroslides

General mechanism: 

Spectrum of activity: Mainly GP cocci (streptococci, staphylococci, campylobacter, helicobacter, borrelia)

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Macroslides

General mechanism: 

Spectrum of activity: Mainly GP cocci (streptococci, staphylococci, campylobacter, helicobacter, borrelia)

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Ketoslides

General mechanism:  Derived from Erythromycin

Spectrum of activity: active against bacteria resistant to macroslides

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Lincosamides

General mechanism: 

Spectrum of activity: GP & anaerobes -> given against staphylococcal bone & joint infections

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Lincosamides

General mechanism: 

Spectrum of activity: GP & anaerobes -> given against staphylococcal bone & joint infections

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group:

General mechanism: Combination of quinupristin & dalfopristin -> synergistic inhibition

Spectrum of activity: GP cocci, modest activity against respiratory pathogens (Moraxella, str. pneumonia, Mycoplasma, Legionella, Chlamydia) % anaerobes

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Oxazolidinones

General mechanism: 

Spectrum of activity: narrow spectrum: GP, some GN (moraxella, pasteurella, bacteroides)

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

General mechanism: 

Spectrum of activity: narrow spectrum: staphylococci (bone and joint); anaerobes (B. fragilis, clostridium); moderate against mycobacteria

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

Group: Mupirocin

General mechanism: <tropical treatment of skin

Spectrum of activity: narrow spectrum: staphylococci, including resistant strains

Inhibition of protein synthesis, alteration of ribosomes & translation, bactericidal or static. depending on dosis

General mechanism: Toxic -> fatal aplastic anemia, leukopenia, penetrates CSF -> against meningitis

Spectrum of activity: Broad spectrum: many GP & GN + anaerobes

-GP: streptococci, staphylococci, Enterococci, B. anthracis, Listeria

-GN: H. influenca, moraxella, neisseria, E.coli, proteus mirabilis, salmonella, shigella, stenothrophomonas maltophilia

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, streptococci

Anti-staphylococcal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, better against Staphylococci

Anti-staphylococcal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, better against Staphylococci

Anti-staphylococcal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, better against Staphylococci

Anti-staphylococcal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, better against Staphylococci

Aminopenicillins

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: Bread sprectrum, GP cocci & some GN rods

Aminopenicillins

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: Bread sprectrum, GP cocci & some GN rods

Antipseudomonal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: Pseudomonas

Antipseudomonal

Group: Penicillin

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: Pseudomonas

Generation 1

Group: Cephalosporins

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, little activity against GN

Generation 2

Group: Cephalosporins

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GN, little activity against GP

Generation 3

Group: Cephalosporins

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GN, resistant to ß-lactamases, variable to GP

Generation 4

Group: Cephalosporins

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GN & GP, enhanced resistance against ß-lactamases

Generation 5

Group: Cephalosporins

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GN, GP & MRSA

Group: Monobactams

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: aerobic GN, pseudomonas and other non-fermentative rods except stenothrophomonas maltophilia

Group: Carbapenems

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, GN -> broad sprectrum 

Group: Carbapenems

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, GN -> broad sprectrum 

Group: Carbapenems

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, GN -> broad sprectrum 

Group: Carbapenems

General mechanism: Bind to PEP -> stops formation of peptide cross links in peptidoglycan

Spectrum of activity: GP, GN -> broad sprectrum